长期饲饮乙醇的大鼠睾丸过氧化脂质的动态变化

被引：2

作者：

李素琴

符云峰

卢振敏

机构：

[1] 河北省医学科学院生化研究室

来源：

男性学杂志 | 1996年 / 04期

关键词：

乙醇,睾丸,脂质过氧化;

D O I：

暂无

中图分类号：

R-332 [医用实验动物学];

学科分类号：

摘要：

本文报告长期饮用１０％乙醇８ｇ／ｋｇｄ－１的雄性Ｓｐｒａｇｕｅ－Ｄａｗｌｅｙ大鼠睾丸组织过氧化脂质（ＬＰＯ）含量动态变化。饮用乙醇３０天、６０天和９０天的大鼠，睾丸组织ＬＰＯ水平均明显高于同期对照大鼠（Ｐ＜０．０１）；在饮用乙醇６０天之内，ＬＰＯ水平呈上升曲线，６０～９０天期间达平顶；每日饲饮乙醇之前给大鼠护肝宁口服液饮用，则睾丸组织ＬＰＯ水平不升高，且明显低于乙醇组大鼠（Ｐ＜０．０１）。结果表明长期饮酒可以引起睾丸组织过氧化损害，护肝宁口服液能够有效地保护睾丸免遭乙醇的毒害。

引用

页码：16 / 18

页数：3

共 9 条

[1]

Effects of alcohol on the hypothalamic - pituitary - gonadal axis in the developing male rat. Little PJ,et al. Journal of Pharmacology and Experimental Therapeutics . 1992

[2]

Ethanol - induced inhibition of testosterone biosynthesis in rat leydig cells: role of culture medium composition. Orpana AK,et al. Journal of Steroid Biochemistry . 1989

[3]

Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Ohkawa H,et al. Analytical Biochemistry . 1979

[4]

Effects of chronic etnanol diet on pituitary - testicular function of the rat. Salonen I,Huhtaniemi I. Biology of Reproduction . 1990

[5]

Acute alcohol exposure markedly influences male fertility and fetal outcome in the male rat. Cicero TJ,et al. Life Sciences . 1994

[6]

Effects of acute and repeated alcohol ingestion on hypothalamic - pituitary - gonadal and hypothalamic - pituitary - adrenal functioning in normal males. Ida Y,et al. Drug and Alcohol Dependence . 1992

[7]

Blood and liver lipid peroxide status after chronic ethanol administration in rats. Coudray C,et al. Clinica Chimica Acta . 1993

[8]

Inhibition of testosterone synthesis by ethanol : role of luteinizing hormone. Widenius TV,et al. Alcohol . 1989

[9]

Lipid peroxidation and antioxidant defense systems in rat liver after chronic ethanol feeding. Kawase T,et al. Hepatology . 1989

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