吉非替尼在非小细胞肺癌治疗中的研究进展

被引:26
作者
卢宝安 [1 ]
张新伟 [2 ]
任秀宝 [2 ]
机构
[1] 天津市静海县医院胸外科
[2] 天津市肿瘤医院
关键词
吉非替尼; 肺肿瘤/治疗学;
D O I
10.13455/j.cnki.cjcor.2010.01.034
中图分类号
R734.2 [肺肿瘤];
学科分类号
100117 [系统生物医学];
摘要
<正>肺癌是全球癌症导致死亡中最常见的病因,占整个肿瘤引起死亡的1/3。80%肺癌为非小细胞肺癌(NSCLC),而70%NSCLC确诊时已属晚期,难以通过手术或放疗进行根治性治疗。另外,超过50%的早期患者尽管经过手术、放疗以及辅助化疗等积极治疗后仍最终出现局部复发或远处转移。
引用
收藏
页码:78 / 81
页数:4
相关论文
共 11 条
[1]
Breast cancer resistance protein (BCRP) affected acquired resistance to gefitinib in a "never-smoked" female patient with advanced non-small cell lung cancer [J].
Usuda, J. ;
Ohira, T. ;
Suga, Y. ;
Oikawa, T. ;
Ichinose, S. ;
Inoue, T. ;
Ohtani, K. ;
Maehara, S. ;
Imai, K. ;
Kubota, M. ;
Tsunoda, Y. ;
Tsutsui, H. ;
Furukawa, K. ;
Okunaka, T. ;
Sugimoto, Y. ;
Kato, H. .
LUNG CANCER, 2007, 58 (02) :296-299
[2]
Erlotinib response of EGFR- mutant gefitinib-resistant non-small-cell lung cancer.[J].John Wen-Cheng Chang;Chun-Liang Chou;Shiu-Feng Huang;Hung-Ming Wang;Jia-Juan Hsieh;Todd Hsu;Yun-Chung Cheung.Lung Cancer.2007, 3
[3]
Pooled analysis of the prospective trials of gefitinib monotherapy for EGFR-mutant non-small cell lung cancers [J].
Costa, Daniel B. ;
Kobayashi, Susumu ;
Tenen, Daniel G. ;
Huberman, Mark S. .
LUNG CANCER, 2007, 58 (01) :95-103
[4]
Epidermal growth factor receptor mutations and their correlation with gefitinib therapy in patients with non-small cell lung cancer: A meta-analysis based on updated individual patient data from six medical centers in mainland China [J].
Wu, Yi-Long ;
Zhong, Wen-Zhao ;
Li, Long-Yun ;
Zhang, Xiao-Tong ;
Zhang, Li ;
Zhou, Cai-Cun ;
Liu, Wei ;
Jiang, Bin ;
Mu, Xin-Lin ;
Lin, Xa-Ying ;
Zhou, Qing ;
Xu, Chong-Rui ;
Wang, Zhen ;
Zhang, Guo-Chun ;
Mok, Tony .
JOURNAL OF THORACIC ONCOLOGY, 2007, 2 (05) :430-439
[5]
Phase II randomized study of daily gefitinib treatment alone or with vinorelbine every 2 weeks in patients with adenocarcinoma of the lung who failed at least 2 regimens of chemotherapy [J].
Chen, Yuh-Min ;
Liu, Jacqueline Ming ;
Chou, Teh-Ying ;
Perng, Reury-Perng ;
Tsai, Chun-Ming ;
Whang-Peng, Jacqueline .
CANCER, 2007, 109 (09) :1821-1828
[6]
Comparative analysis of epidermal growth factor receptor mutations and gene amplification as predictors of gefitinib efficacy in Japanese patients with nonsmall cell lung cancer [J].
Sone, Takashi ;
Kasahara, Kazuo ;
Kimura, Hideharu ;
Nishio, Kazuto ;
Mizuguchi, Masayuki ;
Nakatsumi, Yasuto ;
Shibata, Kazuhiko ;
Waseda, Yuko ;
Fujimura, Masaki ;
Nakao, Shinji .
CANCER, 2007, 109 (09) :1836-1844
[7]
Remarkable effect of gefitinib retreatment in a patient with nonsmall cell lung cancer who had a complete response to initial gefitinib [J].
Yoshimoto, Akihiro ;
Inuzuka, Kanako ;
Kita, Toshiyuki ;
Kawashima, Atsuhiro ;
Kasahara, Kazuo .
AMERICAN JOURNAL OF THE MEDICAL SCIENCES, 2007, 333 (04) :221-225
[8]
Prospective validation for prediction of gefitinib sensitivity by epidermal growth factor receptor gene mutation in patients with non-small cell lung cancer [J].
Yoshida, Kimihide ;
Yatabe, Yasushi ;
Park, Ji Young ;
Shimizu, Junichi ;
Horio, Yoshitsugu ;
Matsuo, Keitaro ;
Kosaka, Takayuki ;
Mitsudomi, Tetsuya ;
Hida, Toyoaki .
JOURNAL OF THORACIC ONCOLOGY, 2007, 2 (01) :22-28
[9]
Gefitinib (IRESSA) in patients of Asian origin with refractory advanced non-small cell lung cancer: Subset analysis from the ISEL study [J].
Chang, Alex ;
Parikh, Purvish ;
Thongprasert, Sumitra ;
Tan, Eng Huat ;
Perng, Reury- Perng ;
Ganzon, Domingo ;
Yang, Chih-Hsin ;
Tsao, Chao-Jung ;
Watkins, Claire ;
Botwood, Nick ;
Thatcher, Nick .
JOURNAL OF THORACIC ONCOLOGY, 2006, 1 (08) :847-855
[10]
A review of the benefit–risk profile of gefitinib in Asian patients with advanced non‐small‐cell lung cancer.[J].Keunchil Park;Koichi Goto.Current Medical Research and Opinion?.2006, 3