442例局限期小细胞肺癌综合治疗分析

被引:15
作者
陈东福
殷蔚伯
王绿化
周宗玫
张湘茹
孙燕
机构
[1] 中国医学科学院中国协和医科大学肿瘤研究所肿瘤医院放射治疗科
[2] 中国医学科学院中国协和医科大学肿瘤研究所肿瘤医院内科
关键词
癌,小细胞肺/化学疗法; 癌,小细胞肺/放射疗法; 综合疗法; 预后;
D O I
暂无
中图分类号
R734.2 [肺肿瘤];
学科分类号
摘要
目的 通过局限期小细胞肺癌先化疗后放射治疗 (先化后放组 )和化疗 +放射治疗 +化疗 (化放化组 ) 2个组的疗效比较 ,分析影响预后因素。方法 局限期小细胞肺癌 442例随机分为先化后放组 (2 2 8例 )和化放化组 (2 1 4例 )。先化后放组为化疗 4周期后放射治疗 ,化放化组为化疗 2周期后放射治疗 1个疗程再化疗 2周期。放射治疗技术和剂量两组相同 ,大多数病例总量DT50~ 70Gy ,5~ 7周 ,照射野包括原发灶、肺门、纵隔及双锁骨上淋巴引流区。化疗方案有COMP、COMVP和CE CAP。结果 全组总有效率为 78.1 % ,局部复发率分别为 34 .6 %和 35 .0 %。 2个组远地转移率分别为 57.5 %和 57.9%。结论  2个组的近期疗效、长期生存、局部复发率和远地转移率均无统计学差异
引用
收藏
页码:20 / 22
页数:3
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