他汀抗炎机制研究新进展

被引:4
作者
孙婧
李全忠
机构
[1] 桂林医学院附属医院心内科
关键词
冠心病; 他汀类药物; 炎症;
D O I
暂无
中图分类号
R541.4 [冠状动脉(粥样)硬化性心脏病(冠心病)];
学科分类号
100201 [内科学];
摘要
冠心病位居全球疾病死亡率第一,占据所有死亡人口的五分之一,他汀类药物(statins)是羟甲基戊二酰辅酶A(HMG-CoA)还原酶抑制剂,广泛应用于冠心病一级预防和二级预防中降低血清胆固醇水平。现主要从冠心病和他汀类药物在天然炎症免疫中的关系作一综述。
引用
收藏
页码:114 / 116
页数:3
相关论文
共 9 条
[1]
辛伐他汀短期干预对不稳定型心绞痛炎性因子的影响 [J].
刘恩代 .
临床合理用药杂志, 2011, 4 (07) :8-9
[2]
PPARs激动剂延缓动脉粥样硬化的研究进展 [J].
马丽娜 ;
陈晓路 ;
王佩显 .
中国实用内科杂志, 2010, 30 (07) :648-649
[3]
Rapid, Direct Effects of Statin Treatment on Arterial Redox State and Nitric Oxide Bioavailability in Human Atherosclerosis via Tetrahydrobiopterin-Mediated Endothelial Nitric Oxide Synthase Coupling [J].
Antoniades, Charalambos ;
Bakogiannis, Constantinos ;
Leeson, Paul ;
Guzik, Tomasz J. ;
Zhang, Mei-Hua ;
Tousoulis, Dimitris ;
Antonopoulos, Alexios S. ;
Demosthenous, Michael ;
Marinou, Kyriakoula ;
Hale, Ashley ;
Paschalis, Andreas ;
Psarros, Costas ;
Triantafyllou, Costas ;
Bendall, Jennifer ;
Casadei, Barbara ;
Stefanadis, Christodoulos ;
Channon, Keith M. .
CIRCULATION, 2011, 124 (03) :335-U176
[4]
Preoperative Atorvastatin Treatment in CABG Patients Rapidly Improves Vein Graft Redox State by Inhibition of Rac1 and NADPH-Oxidase Activity.[J].Charalambos Antoniades;Constantinos Bakogiannis;Dimitris Tousoulis;Svetlana Reilly;Mei-Hua Zhang;Andreas Paschalis;Alexios S. Antonopoulos;Michael Demosthenous;Antigoni Miliou;Costas Psarros;Kyriakoula Marinou;Nikolaos Sfyras;George Economopoulos;Barbara Casadei;Keith M. Channon;Christodoulos Stefanadis.Circulation.2010, 11 S
[5]
Statin Islands and PPAR Ligands in Platelets [J].
Phipps, Richard P. ;
Blumberg, Neil .
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2009, 29 (05) :620-621
[6]
Effect of rosuvastatin in patients with chronic heart failure (the GISSI-HF trial): a randomised, double-blind, placebo-controlled trial [J].
Tavazzi, Luigi ;
Maggioni, Aldo P. ;
Marchioli, Roberto ;
Barlera, Simona ;
Franzosi, Maria Grazia ;
Latini, Roberto ;
Lucci, Donata ;
Nicolosi, Gian Luigi ;
Porcu, Maurizio ;
Tognoni, Gianni .
LANCET, 2008, 372 (9645) :1231-1239
[7]
Subendothelial lipoprotein retention as the initiating process in atherosclerosis -: Update and therapeutic implications [J].
Tabas, Ira ;
Williams, Kevin Jon ;
Boren, Jan .
CIRCULATION, 2007, 116 (16) :1832-1844
[8]
Statin therapy in heart failure: Prognostic effects and potential mechanisms [J].
Shanes, Jeffrey G. ;
Minadeo, Kira N. ;
Moret, Ann ;
Groner, Mordechai ;
Tabaie, Sean A. .
AMERICAN HEART JOURNAL, 2007, 154 (04) :617-623
[9]
Efficacy and safety of cholesterol-lowering treatment: prospective meta-analysis of data from 90,056 participants in 14 randomised trials of statins [J].
Baigent, C ;
Keech, A ;
Kearney, PM ;
Blackwell, L ;
Buck, G ;
Pollicino, C ;
Kirby, A ;
Sourjina, T ;
Peto, R ;
Collins, R ;
Simes, J .
LANCET, 2005, 366 (9493) :1267-1278