缺血再灌注大鼠脑内基质金属蛋白酶的动态变化

被引：8

作者：

徐群

张毅

苏敏

沈沸

苗玲

机构：

[1] 上海第二医科大学仁济医院神经内科

[2] 上海第二医科大学仁济医院神经内科上海

[3] 上海

来源：

上海第二医科大学学报 | 2004年 / 10期

关键词：

基质金属蛋白酶; 脑缺血; 再灌注损伤;

D O I：

暂无

中图分类号：

R741 [神经病学];

学科分类号：

1002 ;

摘要：

目的研究局灶性脑缺血再灌注后基质金属蛋白酶(MMPs)的变化。方法应用含明胶的定量酶谱技术,检测大鼠局灶性脑缺血再灌注7 d内MMP-2和MMP-9的表达。结果 MMP-9(92 kd)在假手术组和手术组非缺血侧没有或仅有极低量的表达,手术组缺血侧再灌注3 h后开始出现MMP-9表达,24、48 h较假手术组显著升高(P<0.05,P<0.01),并显著高于其它各组(P<0.05)。MMP-2(72 kd)在各组缺血侧与非缺血侧均有表达,48 h缺血侧开始较假手术组升高(P<0.05),7 d到达高峰;3 h和24 h与7 d相比,有显著性差别(均P<0.01)。各组非缺血侧之间无显著差别(P>0.05)。结论脑缺血再灌注后MMP-9和MMP-2的水平升高;MMP-9上调可能与缺血再灌注后的炎症损伤有关,MMP-2可能与炎症反应损伤后的修复过程相关。

引用

页码：814 / 817

页数：4

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