重症手足口病分组监护治疗80例分析

被引:74
作者
何颜霞 [1 ]
付丹 [1 ]
操德智 [1 ]
刘红艳 [1 ]
黄雀兰 [1 ]
李成荣 [1 ]
机构
[1] 深圳市儿童医院PICU隔离病房
关键词
手足口病; 重症监护病房; 儿科; 病毒性疾病; 肠道病毒感染; 磁共振成像;
D O I
暂无
中图分类号
R686 [筋腱、韧带、滑囊疾病及损伤];
学科分类号
1002 ; 100210 ;
摘要
目的探讨阻止重症手足口病向危重症进展以及提高危重症抢救成功率的救治方案。方法根据有无神经系统和其他并发症及其程度,将80例重症手足口病患儿分为A、B、C、D 3组。各组分别给予不同强度监护治疗方案,分析总结各组疗效及预后。统计学处理使用SPSS13.0软件,统计学方法采用方差分析或卡方检验。结果重症手足口病累及神经系统受累时,最多出现的症状是持续发热(69/70)和四肢抖动(67/70),病情重者皮疹相对少。脑干病变伴肺水肿者常出现心动过速>200次/min、血压升高、外周血白细胞增高、血糖增高。脑脊液细胞数、CRP与病情轻重无关。神经系统受累与EV71感染高度相关。A、B、C 3组共69例,全部治愈。D组11例,其中6例并发神经源性肺水肿和循环衰竭,死亡2例,9例抢救成功,其中8例痊愈,1例遗留智障及运动障碍。结论神经系统受累的手足口病重症病例,及时合理使用甘露醇、甲基泼尼松龙、丙种球蛋白以及其他对症支持措施,可能对阻止重症病例向危重状态发展和降低危重症病死率有益。
引用
收藏
相关论文
共 6 条
  • [1] Risk factors of enterovirus 71 infection and associated hand, foot, and mouth disease/herpangina in children during an epidemic in Taiwan. Chang LY,King CC,Hsu KH, et al. Pediatrics . 2002
  • [2] Deaths of children during an outbreak of hand, foot, and mouth disease in sarawak, malaysia: clinical and pathological characteristics of the disease. For the Outbreak Study Group. Chan LG,Parashar UD,Lye MS, et al. Clinical Infectious Diseases . 2000
  • [3] Epidemic hand, foot and mouth disease caused by human enterovirus 71, Singapore. Chan KP,Goh KT,Chang CY, et al. Emerging Infectious Diseases . 2003
  • [4] An epidemic of enterovirus 71 infection in Taiwan. Ho M,Chen E R,Hsu K H,et al. The New England Journal of Medicine . 1999
  • [5] Outcome of enterovirus 71 infections with or without stage-based management:1998 to 2002. Chang LY,Hsia SH,Wu CT,et al. Pediatric Infectious Disease . 2004
  • [6] Different proinflammatory reactions in fatal and non-fatal entemvirus 71 infections: implications for early recognition and therapy. Lin TY,Chang LY,Huang YC, et al. Acta Paediatrica . 2002