α-突触核蛋白与帕金森病关系的研究进展

被引：7

作者：

陈琳

彭芳

郁可

林杭

王庆松

机构：

[1] 中国人民解放军成都军区总医院神经内科

来源：

广东医学 | 2013年 / 34卷 / 23期

关键词：

D O I：

10.13820/j.cnki.gdyx.2013.23.051

中图分类号：

R742.5 [震颤麻痹综合征];

学科分类号：

100204 [神经病学];

摘要：

<正>自1817年James Parkinson首次描述帕金森病(Parkinson disease,PD)为"震颤麻痹"以来,人类对PD的认识已有200年来的进展,无论从病因和发病机制的认识,还是对其诊断和治疗手段的探索,都有了长足的进步。迄今为止,PD的发病机制仍不完全清楚,但PD典型的病理改变是形成路易体(Lewy body,LB),而α-突触核蛋白(α-synuclein,α-syn)是LB的主要成分,α-syn可能从多个方面影响PD发病机制,原因通常归咎于其异常的可溶性低聚物构象,亦称为淀粉样纤维化。因此,α-syn在PD的发病中可能起到关键作用,并可能为治疗PD带来新的策略,对其他神经系统退行疾病的治疗也有帮助。本文综述α-syn与PD之间的联系。

引用

页码：3677 / 3679

页数：3

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