Rho/Rho激酶信号通路与糖尿病肾病

被引：3

作者：

马东蔚

王秋月

机构：

[1] 中国医科大学附属第一医院内分泌科

来源：

国际内分泌代谢杂志 | 2011年 / 03期

关键词：

Rho; Rho/ROCK信号通路; 肾纤维化; 糖尿病肾病;

D O I：

暂无

中图分类号：

R285.5 [中药实验药理];

学科分类号：

摘要：

糖尿病肾病(DN)是糖尿病重要的微血管并发症之一,其发病机制是多种因素共同作用的结果。近年来发现Rho/Rho激酶(Rho/ROCK)信号通路与多种组织重构如血管、心肌、肾纤维化等相关。高糖能够刺激肾脏细胞内Rho/ROCK信号通路的激活,后者通过调控转录因子的DNA结合活性上调多种基因的表达,从而引起各种炎性反应及肾小球纤维化,而应用此信号通路选择性抑制剂后可明显改善DN的发生和发展,从而认为Rho/ROCK信号转导通路可能在DN的发病机制中起关键作用。

引用

页码：193 / 195 +199

共 9 条

[1] Rho-kinase mediates TNF-α-induced MCP-1 expression via p38 MAPK signaling pathway in mesangial cells [J].

Matoba, Keiichiro ;

Kawanami, Daiji ;

Ishizawa, Sho ;

Kanazawa, Yasushi ;

Yokota, Tamotsu ;

Utsunomiya, Kazunori .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2010, 402 (04) :725-730

[2] Therapeutic Effect of Y-27632 on Chronic Allograft Nephropathy in Rats [J].

Liu, Min ;

Gu, Min ;

Wu, Yichao ;

Zhu, Pengcheng ;

Zhang, Wei ;

Yin, Changjun ;

Zhang, Wei .

JOURNAL OF SURGICAL RESEARCH, 2009, 157 (01) :E117-E127

[3] Helicobacter pylori Dysregulation of Gastric Epithelial Tight Junctions by Urease-Mediated Myosin II Activation [J].

Wroblewski, Lydia E. ;

Shen, Le ;

Ogden, Seth ;

Romero-Gallo, Judith ;

Lapierre, Lynne A. ;

Israel, Dawn A. ;

Turner, Jerrold R. ;

Peek, Richard M., Jr. .

GASTROENTEROLOGY, 2009, 136 (01) :236-246

[4] RhoA/Rho-kinase contribute to the pathogenesis of diabetic renal disease [J].

Peng, Fangfang ;

Wu, Dongcheng ;

Gao, Bo ;

Ingram, Alistair J. ;

Zhang, Baifang ;

Chorneyko, Katherine ;

McKenzie, Rick ;

Krepinsky, Joan C. .

DIABETES, 2008, 57 (06) :1683-1692

[5] Targeting of RhoA/ROCK signaling ameliorates progression of diabetic nephropathy independent of glucose control [J].

Kolavennu, Vasantha ;

Zeng, Lixia ;

Peng, Hui ;

Wang, Yin ;

Danesh, Farhad R. .

DIABETES, 2008, 57 (03) :714-723

[6]

Contraction of tubulointerstitial fibrosis tissue in diabetic nephropathy, as demonstrated in an in vitro fibrosis model[J] . Keisuke Ina,Hirokazu Kitamura,Shuji Tatsukawa,Takashi Miyazaki,Hirokazu Abe,Yoshihisa Fujikura.Virchows Archiv . 2007 (5)

[7]

The Rho-kinase inhibitor, fasudil, attenuates diabetic nephropathy in streptozotocin-induced diabetic rats[J] . Atsushi Gojo,Kazunori Utsunomiya,Kanta Taniguchi,Tamotsu Yokota,Shoh Ishizawa,Yasushi Kanazawa,Hideaki Kurata,Naoko Tajima.European Journal of Pharmacology . 2007 (1)

[8] Long-term administration of Rho-kinase inhibitor ameliorates renal damage in malignant hypertensive rats [J].

Ishikawa, Yayoi ;

Nishikimi, Toshio ;

Akimoto, Kazumi ;

Ishimura, Kimihiko ;

Ono, Hidehiko ;

Matsuoka, Hiroaki .

HYPERTENSION, 2006, 47 (06) :1075-1083

[9]

Molecularmechanisms and therapeutic strategies of chronic renal injury:Role of rho-kinase in the development of renal injury .2 HayashiK,Wakino S,Kanda T,et al. J Pharmacol Sc,i . 2006

← 1 →