“肌少-骨质疏松症”的共同发病机制

被引：52

作者：

陈锦成 ^{[1
,2
]}

朱国涛 ^{[1
,2
]}

刘洪文 ^{[1
,2
]}

陈彦丞 ^{[3
]}

罗骏 ^{[2
]}

秦晓飞 ^{[1
,2
]}

徐杰 ^{[1
,2
]}

机构：

[1] 福建中医药大学中医骨伤及运动康复教育部重点实验室

[2] 福建省立医院骨二科

[3] 福建医科大学省立临床医学院

来源：

中华骨质疏松和骨矿盐疾病杂志 | 2020年 / 13卷 / 01期

关键词：

肌少症; 骨质疏松症; 病理生理学; 共同发病机制;

D O I：

暂无

中图分类号：

R580 [];

学科分类号：

摘要：

"肌少-骨质疏松症"(sarco-osteopenia)的提出是基于两者共同的病理生理学基础,其中涉及八类主要影响因素。简要概括为机械因素作用于骨细胞构成的机械支架和肌管;肌肉-骨骼系统相互影响彼此化学因子的释放;甲基转移酶样蛋白21C (METTL21C)和肌肉生长抑制素(myostatin,MSTN,简称肌抑素)以及硬骨抑素(sclerostin,SOST)作为共同的遗传因素调控肌肉-骨骼系统;肌肉和骨骼在旁分泌和内分泌水平上的串扰、脂肪浸润因素导致肌力的下降和骨折发生率增加;炎性反应、糖尿病和糖皮质激素过量影响肌肉的丢失以及骨丢失;营养缺乏加速骨丢失和肌肉蛋白质合成减少;个体运动量的减少和神经-肌肉功能减弱间接影响肌肉和骨骼的合成代谢。深入研究"肌少-骨质疏松症"共同的致病机制,以推动生物检测特异性指标的确定、临床疾病的评估和诊断以及有效治疗药物和设备开发工作,最终目标是有效地治疗和预防"肌少-骨质疏松症"。本文对"肌少-骨质疏松症"共同病理生理学机制研究现状与进展进行系统综述。

引用

收藏

页码：95 / 102

页数：8

相关论文

共 32 条

[1]

Contribution of Heritability and Epigenetic Factors to Skeletal Muscle Mass Variation in United Kingdom Twins [J].

Livshits, Gregory ;

Gao, Fei ;

Malkin, Ida ;

Needhamsen, Maria ;

Xia, Yudong ;

Yuan, Wei ;

Bell, Christopher G. ;

Ward, Kirsten ;

Liu, Yuan ;

Wang, Jun ;

Bell, Jordana T. ;

Spector, Tim D. .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2016, 101 (06) :2450-2459

[2]

Osteocalcin Signaling in Myofibers Is Necessary and Sufficient for Optimum Adaptation to Exercise [J].

Mera, Paula ;

Laue, Kathrin ;

Ferron, Mathieu ;

Confavreux, Cyril ;

Wei, Jianwen ;

Galan-Diez, Marta ;

Lacampagne, Alain ;

Mitchell, Sarah J. ;

Mattison, Julie A. ;

Chen, Yun ;

Bacchetta, Justine ;

Szulc, Pawel ;

Kitsis, Richard N. ;

de Cabo, Rafael ;

Friedman, Richard A. ;

Torsitano, Christopher ;

McGraw, Timothy E. ;

Puchowicz, Michelle ;

Kurland, Irwin ;

Karsenty, Gerard .

CELL METABOLISM, 2016, 23 (06) :1078-1092

[3]

Interactions Between Muscle Tissues and Bone Metabolism [J].

Kawao, Naoyuki ;

Kaji, Hiroshi .

JOURNAL OF CELLULAR BIOCHEMISTRY, 2015, 116 (05) :687-695

[4]

METTL21C Is a Potential Pleiotropic Gene for Osteoporosis and Sarcopenia Acting Through the Modulation of the NF-κB Signaling Pathway [J].

Huang, Jian ;

Hsu, Yi-Hsiang ;

Mo, Chenglin ;

Abreu, Eduardo ;

Kiel, Douglas P. ;

Bonewald, Lynda F. ;

Brotto, Marco ;

Karasikz, David .

JOURNAL OF BONE AND MINERAL RESEARCH, 2014, 29 (07) :1531-1540

[5]

Active vitamin D possesses beneficial effects on the interaction between muscle and bone [J].

Tanaka, Ken-ichiro ;

Kanazawa, Ippei ;

Yamaguchi, Toru ;

Yano, Shozo ;

Kaji, Hiroshi ;

Sugimoto, Toshitsugu .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2014, 450 (01) :482-487

[6]

Physiology of mechanotransduction: How do muscle and bone "talk" to one another? [J].

Isaacson J. ;

Brotto M. .

Clinical Reviews in Bone and Mineral Metabolism, 2014, 12 (2) :77-85

[7]

Evidence for an Interaction Between Exercise and Nutrition for Improving Bone and Muscle Health [J].

Daly, Robin M. ;

Duckham, Rachel L. ;

Gianoudis, Jenny .

CURRENT OSTEOPOROSIS REPORTS, 2014, 12 (02) :219-226

[8]

Clinical outcomes of impaired muscle and bone interactions [J].

Demontiero O. ;

Boersma D. ;

Suriyaarachchi P. ;

Duque G. .

Clinical Reviews in Bone and Mineral Metabolism, 2014, 12 (2) :86-92

[9]

What's in a name revisited: should osteoporosis and sarcopenia be considered components of "dysmobility syndrome?" [J].

Binkley, N. ;

Krueger, D. ;

Buehring, B. .

OSTEOPOROSIS INTERNATIONAL, 2013, 24 (12) :2955-2959

[10]

The Osteocyte: An Endocrine Cell … and More.[J].Sarah L. Dallas;Matthew Prideaux;Lynda F. Bonewald.Endocrine Reviews.2013, 5

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