糖尿病鼠的骨和钙磷代谢紊乱及胰岛素的防治作用

被引：7

作者：

张新州 ^{[1
]}

施曼珠 ^{[1
]}

党耕町 ^{[2
]}

机构：

[1] 北京医科大学第一医院内科

[2] 北京医科大学第三医院骨科

来源：

中华内科杂志 | 1992年 / 11期

关键词：

糖尿病; 骨疾病; 胰岛素;

D O I：

暂无

中图分类号：

R587 [胰岛疾病];

学科分类号：

摘要：

我们应用非脱钙骨组织形态测量、单光子吸收扫描和骨物理测量方法对链尿佐菌素所致的糖尿病鼠、胰岛素早期和晚期治疗糖尿病鼠及正常鼠的骨组织形态、骨的生长、骨矿物质含量和钙磷代谢进行了14周的观察和研究。结果提示:糖尿病鼠存在严重的骨和矿物质代谢紊乱。胰岛素早期治疗可以预防晚期治疗可以纠正糖尿病引起的骨量减少,骨重建单位负平衡和骨生长受抑。糖尿病的代谢紊乱和(或)胰岛素缺乏对骨的改变可能有直接作用。胰岛素的治疗作用是直接作用于骨组织本身的结果,还是通过改善代谢,纠正钙磷代谢紊乱的结果仍需进一步探讨。

引用

页码：674 / 677 +729

共 15 条

[1] Quantitative structural analysis of human cancellous bone. Merz,W.A.,Shenk,R.K. Acta Anat. (Basel) . 1970
[2] Handbook of microscopical technique, ed 3. Jones R,McClung A. Journal of Women s Health . 1950
[3] Diabetes mellitus and risk of skeletal fracture. Heath. H,et al. The New England Journal of Medicine . 1980
[4] The effect of streptozotocininduced chronic diabetes mellitus on bone and mineral homeostasis in the rat. Roy Shires,et al. Journal of Laboratory and Clinical Medicine . 1981
[5] Handbook of microscopical technique, ed 3. Jones R,McClung A. . 1950
[6] Demonstration of insulin receptors and modulation of alkaline phosphatase activity by insulin in rat osteoblastic cells. Levy JR,et al. The Journal of Endocrinology . 1986
[7] Characterization of insulin on collagen synthesis in fetal rat bone. Kream BE,et al. The Journal of Endocrinology . 1985
[8] Correction of abnormal bone and mineral metabolism in chronic streptozotocin-induced diabetes mellitus in the rat by insulin therapy. Stephen Hought,et al. The Journal of Endocrinology . 1981
[9] Effects of diabetes mellitus on bone mass in juvenile and adult onset diabetes. Levin ME,et al. The New England Journal of Medicine . 1976
[10] Demonstration of insulin receptors and modulation of alkaline phosphatase activity by insulin in rat osteoblastic cells. Levy J R,Murray E,Manolagas S,et al. The Journal of Endocrinology . 1986

← 1 2 →