心房颤动与心房纤维化机制的研究

被引：7

作者：

张超

刘旭

机构：

[1] 上海交通大学附属胸科医院心内科

来源：

国际心血管病杂志 | 2011年 / 38卷 / 04期

关键词：

心房颤动; 心房纤维化; 疾病模型; 病理生理学;

D O I：

暂无

中图分类号：

R541.75 [];

学科分类号：

1002 ; 100201 ;

摘要：

心房颤动(AF)是临床上常见的心律失常,65岁以上的老年人将近5%患有AF,心房纤维化为AF的发生和维持提供病理基础。研究显示,心房间质纤维化随着年龄增长而增加,在AF患者、衰老的动物模型以及充血性心力衰竭(CHF)患者中,同样观察到心肌间质纤维化的现象。在CHF的动物模型和选择性心房纤维化的转基因小鼠模型研究中发现,心房间质纤维化增加了AF的易感性。研究都提示,心房纤维化可能是AF的病理基础。为此,该文对心房纤维化在AF发展的机制研究进行综述。

引用

页码：213 / 216

页数：4

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