肠道微生态与肠易激综合征:基础与临床

被引：25

作者：

王鹏

李延青

机构：

[1] 山东大学齐鲁医院消化内科

来源：

胃肠病学 | 2019年 / 24卷 / 04期

关键词：

肠道菌群; 肠易激综合征; 菌群-肠-脑轴; 有益菌种;

D O I：

暂无

中图分类号：

R574.4 [肠道功能紊乱];

学科分类号：

100201 [内科学];

摘要：

肠道微生态与功能性胃肠病(FGIDs)的关系已成为目前研究热点之一。最新罗马Ⅳ标准指出FGIDs不仅仅是胃肠道疾病,脑-肠互动障碍可能贯穿肠易激综合征(IBS)发病的始终。肠道微生态失衡被认为是导致脑-肠互动障碍的重要始动因素,参与构成菌群-肠-脑轴,成为新兴研究热点。尤其是在IBS的研究中,肠道微生态失衡已被证实与IBS免疫异常和临床症状相关;使用益生菌调节IBS肠道菌群取得良好成效,其他相关菌群干预策略也在不断探索中。

引用

收藏

页码：193 / 197

页数：5

相关论文

共 14 条

[1]

Systematic review with meta-analysis: the efficacy of prebiotics, probiotics, synbiotics and antibiotics in irritable bowel syndrome [J].

Ford, Alexander C. ;

Harris, Lucinda A. ;

Lacy, Brian E. ;

Quigley, Eamonn M. M. ;

Moayyedi, Paul .

ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 2018, 48 (10) :1044-1060

[2]

FODMAPs alter symptoms and the metabolome of patients with IBS: a randomised controlled trial [J].

McIntosh, Keith ;

Reed, David E. ;

Schneider, Theresa ;

Dang, Frances ;

Keshteli, Ammar H. ;

De Palma, Giada ;

Madsen, Karen ;

Bercik, Premysl ;

Vanner, Stephen .

GUT, 2017, 66 (07) :1241-1251

[3]

Gut Microbiota Modulation and Mucosal Immunity: Focus on Rifaximin [J].

Lopetuso, Loris R. ;

Petito, Valentina ;

Scaldaferri, Franco ;

Gasbarrini, Antonio .

MINI-REVIEWS IN MEDICINAL CHEMISTRY, 2016, 16 (03) :179-185

[4]

Altered faecal and mucosal microbial composition in post-infectious irritable bowel syndrome patients correlates with mucosal lymphocyte phenotypes and psychological distress [J].

Sundin, J. ;

Rangel, I. ;

Fuentes, S. ;

Heikamp-de Jong, I. ;

Hultgren-Hornquist, E. ;

de Vos, W. M. ;

Brummer, R. J. .

ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 2015, 41 (04) :342-351

[5]

Is fecal microbiota transplantation (FMT) an effective treatment for patients with functional gastrointestinal disorders (FGID)? [J].

Pinn, D. M. ;

Aroniadis, O. C. ;

Brandt, L. J. .

NEUROGASTROENTEROLOGY AND MOTILITY, 2015, 27 (01) :19-29

[6]

Microbial endocrinology.[J].Mark Lyte.Gut Microbes.2014, 3

[7]

Rifaximin Alters Intestinal Bacteria and Prevents Stress-Induced Gut Inflammation and Visceral Hyperalgesia in Rats [J].

Xu, Dabo ;

Gao, Jun ;

Gillilland, Merritt, III ;

Wu, Xiaoyin ;

Song, Il ;

Kao, John Y. ;

Owyang, Chung .

GASTROENTEROLOGY, 2014, 146 (02) :484-+

[8]

Therapeutic faecal microbiota transplantation: current status and future developments [J].

Borody, Thomas J. ;

Brandt, Lawrence J. ;

Paramsothy, Sudarshan .

CURRENT OPINION IN GASTROENTEROLOGY, 2014, 30 (01) :97-105

[9]

Fecal excretion of Bifidobacterium infantis 35624 and changes in fecal microbiota after eight weeks of oral supplementation with encapsulated probiotic [J].

Charbonneau, Duane ;

Gibb, Roger D. ;

Quigley, Eamonn M. M. .

GUT MICROBES, 2013, 4 (03) :201-211

[10]

Altered profiles of intestinal microbiota and organic acids may be the origin of symptoms in irritable bowel syndrome [J].

Tana, C. ;

Umesaki, Y. ;

Imaoka, A. ;

Handa, T. ;

Kanazawa, M. ;

Fukudo, S. .

NEUROGASTROENTEROLOGY AND MOTILITY, 2010, 22 (05) :512-+