谷胱甘肽还原酶循环法测定血浆谷胱甘肽含量在肿瘤化疗中的意义

被引：7

作者：

蔡鹏

刘叙仪

王萍

机构：

[1] 北京市肿瘤防治研究所!北京市

来源：

中国肿瘤临床 | 1994年 / 10期

关键词：

恶性肿瘤; 血浆谷胱甘肽; 化疗耐药;

D O I：

暂无

中图分类号：

R730.53 [化学（药物）疗法];

学科分类号：

100214 ;

摘要：

肿瘤细胞内谷胱甘肽增加与含铂类、烷化剂及含醌类等抗癌药物的耐药性有关.本文用谷胱甘肽还原酶循环法(Glutathione Reductase Recycling Assay)测定40例正常人,20例化疗前恶性肿瘤病人及20例以顺铂、环磷酰胺及阿霉素为主的化疗病人的血浆谷胱甘肽含量.化疗后病人血浆谷胱甘肽含量比正常人及化疗前者明显增高(P<0.01),而化疗前病人与正常人无显著差异(P>0.05).提示血浆谷胱甘肽增高与长期运用顺铂、环磷酰胺及阿霉素等药有关.5例临床产生耐药者血浆谷胱甘肽明显高于化疗组平均值(P<0.01),故可能与临床耐药有一定相关性.

引用

页码：6 / 8

页数：3

共 9 条

[1]

Glutathione metabolism as a determinant of therapeutic efficacy:a review. Arrick B A,Nathan C F. Cancer Research . 1984

[2]

Relationship of cellular glutathione to the cytotixicity and resistance of seven platinum compounds. Meijer C,et al. Cancer Research . 1992

[3]

Changes in cellular glutathione content during adriamycin treatment in human ovarian cancer—a possible indicator of chemosensitivity. Lee F Y F,et al. British Journal of Cancer . 1989

[4]

The role of glutathione in resistance to cisplatin in a human small cell lung cancer cell line. Meijer C,et al. British Journal of Cancer . 1990

[5]

Glutathione. Meister A,Andorson M E. Annual Review of Biochemistry . 1983

[6]

The role of detoxifying systems in resistance of tumor cell to cisplatin and adriamycin. Meijer C,et al. Cancer Treatment Reviews . 1990

[7]

Heterogeneity of glutathione content in human ovarian cancer. Lee F Y F,et al. Cancer Research . 1989

[8]

Determination of glutathione and glutathione disulfide using glutathione reductase and 2vinylpyridine. Griffith O W. Analytical Biochemistry . 1980

[9]

Determination of glutathione and glutathione disulfide in biological samples. Anderson M E. Methods in Enzymology . 1985

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