反流性食管炎患者血浆血管活性肠肽、胃动素变化及其意义

被引:9
作者
程文芳
易粹琼
机构
[1] 湖北黄石市中心医院消化科
[2] 同济医科大学附属协和医院消化科 黄石
关键词
反流性食管炎; 下食管括约肌压力; 血管活性肠肽; 胃动素;
D O I
暂无
中图分类号
R571 [食管疾病];
学科分类号
1002 ; 100201 ;
摘要
目的:测定反流性食管炎患者血浆血管活性肠肽(VIP)、胃动素浓度,及下食管括约肌压力(LESP),以探讨反流性食管炎的发病机制。方法:采用液体灌注体外传感器法测定28例反流性食管炎患者下食管括约肌压力。采用放射免疫法测定其血浆VIP及胃动素浓度。结果:病例组血浆VIP浓度与对照组差异有显著性(P<0.05)。LESP与血浆VIP浓度呈明显负相关(r=-0.912.P<0.01)。病例组血浆胃动素浓度与对照差异有显著性(P<0.05)。LESP与血浆胃动素浓度无相关性。结论:反流性食管炎患者存在胃肠激素异常,其中血浆VIP升高,胃动素降低。血浆VIP升高可降低LESP,而胃动素降低对LESP无影响。
引用
收藏
页码:9 / 10
页数:2
相关论文
共 6 条
[1]  
High vasoactive intestinal polypeptide plasma level in patients with Barrett‘s esophagus. A Rossilor M,Gurlrud PF,et al. Scandinavian Journal of Gastroenterology . 1993
[2]  
Interdigestive gastrodudenal motility and serum motilin level in patients with idiopathic delay in gastric emptying. Labo G,Brotolett P,et al. Gastroenterology . 1986
[3]  
Gastroesophageal reflux disease is associated with enteric hormone abnormalities. Galen Perdikis MD,Paulwison,et al. The American Journal of Surgery . 1994
[4]  
Vasoactive intstinal Polypeptide a neurotransmitter for lower esophageal sphincter relaxation. Biancani P,Walsh JH,et al. The Journal of Clinical Investigation . 1984
[5]  
VIP as a possible neurotransmitter of nonadrenergic noncholinergic neurones. Goyal RK,Rultan S,Said SI. Nature . 1980
[6]  
Neurohormonal,hormonal and drug receptor for the lower esophageal sphincter. Goyal RK,McGugan JE. Gastroenterology . 1979