2型糖尿病患者冠状动脉粥样硬化与视网膜病变的关系

被引：8

作者：

魏富春 ^{[1
]}

戎健 ^{[2
]}

陈玉群 ^{[3
]}

干雪梅 ^{[4
]}

于长青 ^{[4
]}

陈静 ^{[4
]}

杨沛 ^{[4
]}

陈金华 ^{[4
]}

机构：

[1] 部队医院

[2] 成都军区总医院地干病房/老年病科

[3] 第三军医大学西南医院

[4] 第三军医大学大坪医院

来源：

中国动脉硬化杂志 | 2013年 / 21卷 / 08期

关键词：

2型糖尿病; 视网膜病变; 冠状动脉粥样硬化; 计算机断层扫描血管造影术;

D O I：

暂无

中图分类号：

R587.1 [糖尿病]; R774.1 [视网膜疾病];

学科分类号：

摘要：

目的采用64层螺旋CT血管造影(MDCT),探讨2型糖尿病患者冠状动脉粥样硬化(CAs)与糖尿病视网膜病变(DR)的关系。方法诊断为CAs的2型糖尿病患者114例,无CAs的患者124例,受试者均进行眼底彩色照相、MDCT检查和体格检查,并测定空腹血糖、糖化血红蛋白、血脂、肾小球滤过率估计值和尿白蛋白排泌率等,分析检查和检测结果间的相关关系。结果 CAs患者DR发生率为67.5%,显著高于无CAs患者(33.1%,P<0.001)。在调整传统心血管病危险因素后CAs与DR独立相关,仍然具有统计学意义(OR=5.0,95%CI:2.6～9.8);发生CAs的血管数在无DR患者、增殖型DR前期患者及增殖型DR患者中逐渐增加(P<0.01);CAs发生率、有3支以上血管受损的CAs发生率、有意义CAs(管腔狭窄超过50%)发生率以及受损血管百分比也随DR的发生与发展而显著增加(无DR、增殖型DR前期、增殖型DR比较,P值均小于0.01)。结论 CAs发生范围和严重程度随DR的发生与发展而增加,CAs和DR仍然是多因素作用所致,可能有共同发病机制。

引用

页码：732 / 736

页数：5

共 21 条

[1]

Nephropathy in diabetes. American Diabetes Association. Diabetes Care . 2004

[2]

The relation of atherosclerotic cardiovascular disease to retinopathy in people with diabetes in the Cardiovascular Health Study. R. Klein,E.K. Marino,L.H. Kuller. British Journal of Ophthalmology . 2002

[3]

Effect of Trandolapril on Regression of Retinopathy in Hypertensive Patients with Type 2 Diabetes: A Prespecified Analysis of the Benedict Trial[J] . Piero Ruggenenti,Ilian Iliev,Marco Filipponi,Stefano Tadini,Annalisa Perna,Maria Ganeva,Bogdan Ene-Iordache,Paolo Cravedi,Roberto Trevisan,Antonio Bossi,Giuseppe Remuzzi,Renu A. Kowluru. &nbspJournal of Ophthalmology . 2010

[4]

Wall thickening of common carotid arteries in patients affected by noninsulin-dependent diabetes mellitus:relationship to microvascular complications. VisonàA,Lusiani L,Bonanome A,et al. Angiology . 1995

[5] Diabetic retinopathy [J].

Cheung, Ning ;

Mitchell, Paul ;

Wong, Tien Yin .

LANCET, 2010, 376 (9735) :124-136

[6]

A symptomatic coronary heart disease in patients with type 2 diabetes with vascular complications:a cross-sectional study. Tsujimoto T,Kajio H,Takahashi Y,et al. BMJ Open . 2011

[7]

A Reporting System on Patients Evaluated for Coronary Artery Disease[J] . W. GERALD AUSTEN,JESSE E. EDWARDS,ROBERT L. FRYE,GOFFREDO G. GENSINI,VINCENT L. GOTT,LAWRENCE S. C. GRIFFITH,DWIGHT C. MCGOON,MARVIN L. MURPHY,BENSON B. ROE. &nbspCirculation . 1975 (4)

[8]

Advanced Glycation End Products (AGEs), Oxidative Stress and Diabetic Retinopathy[J] . Sho-ichi Yamagishi,Takanori Matsui. &nbspCurrent Pharmaceutical Biotechnology . 2011 (3)

[9]

Modified glomerular filitration rate estimating equation for Chinese patients with chronic kidney disease. Ma YC,Zuo L,Chen JH,et al. Journal of the American Society of Nephrology . 2006

[10] Proposed international clinical diabetic retinopathy and diabetic macular edema disease severity scales [J].

Wilkinson, CP ;

Ferris, FL ;

Klein, RE ;

Lee, PP ;

Agardh, CD ;

Davis, M ;

Dills, D ;

Kampik, A ;

Pararajasegaram, R ;

Verdaguer, JT .

OPHTHALMOLOGY, 2003, 110 (09) :1677-1682

← 1 2 3 →