厨房油烟引起AL细胞遗传损伤和胞内自由基形成

被引：7

作者：

章树业

胡步荣

许安

机构：

[1] 中科院离子束生物工程学重点实验室

[2] 中科院离子束生物工程学重点实验室中国安徽合肥

[3] 中国安徽合肥

来源：

激光生物学报 | 2004年 / 05期

关键词：

厨房油烟; 细胞遗传毒性; 突变; 活性氧自由基;

D O I：

暂无

中图分类号：

R363 [病理生理学];

学科分类号：

100104 ;

摘要：

为了解厨房油烟(cookingoilfumes,COF)对细胞的危害及其遗传毒性机制,以AL细胞为实验模型,对细胞活力水平、细胞基因突变率、细胞非巯基蛋白化合物水平(NPSH)以及细胞内活性氧(ROS)产生的变化规律进行了研究。实验发现:用厨房油烟(COF)处理后,AL细胞的活力下降,细胞CD59基因的突变率随着处理浓度的增加而增加,NPSH水平随着处理浓度的增加而降低,且存在一定的剂量-效应关系。检测胞内产生的ROS,发现400μg/mlCOF处理30min后,细胞内ROS含量高于对照3倍多。实验结果表明:COF可引起细胞氧化胁迫,诱导哺乳动物细胞基因突变。

引用

页码：339 / 344

页数：6

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