无偿献血者隐匿性乙型肝炎病毒感染的血清学研究

被引:4
作者
石兰珍
傅广成
陈兰娟
机构
[1] 义乌市中心血站
关键词
无偿献血; 隐匿性乙型肝炎病毒感染;
D O I
暂无
中图分类号
R512.62 [];
学科分类号
摘要
目的了解无偿献血者隐匿性乙型肝炎病毒(HBV)感染的血清学状况,减少输血传播HBV感染风险。方法收集乙肝表面抗原(HBsAg)阴性无偿献血者可疑HBV感染血液2175份,所有血液标本均通过ELISA法检测血清HBV相关标志物,抗-HBC阳性血清再通过PCR检测HBV DNA。结果 2175例HBsAg阴性标本共有抗-HBC阳性标本700例(32.2%),单独抗-HBC阳性者有153例,抗-HBC和抗-HBs同时阳性有260例,其中有32.0%(224/700)为抗-HBs弱阳性,有46.1%(323/700)为抗-HBs强阳性。抗-HBC阳性标本中HBV DNA阳性率为4.7%(33/700)。HBV DNA阳性标本中有57.6%(19/33)为抗-HBs阴性,有39.4%(13/33)为抗-HBs弱阳性,有3.0%(1/33)为抗-HBs强阳性。结论无偿献血者存在隐匿性HBV感染,有必要重视无偿献血者初筛HBsAg阴性人群的进一步血清学检测。
引用
收藏
页码:2945 / 2947
页数:3
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