阿尔采木病流行病学新观点

被引:1
作者
Robert Katzman
机构
关键词
淀粉样前体蛋白; 危险因素; 脱失; 外伤; 危险度; 病人; 危险隐患; 危险系数; AD; 神经突触; 流行病学; 神经原纤维缠结;
D O I
暂无
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学科分类号
摘要
新近的流行病学研究指出:年龄、痴呆家族史、头外伤、冠状动脉病和缺乏教育是AD的危险因素。一可能的生物学解释为:遗传、外伤和缺血等,使淀粉样前体蛋白生成增加;进而产生弥教斑块;后者作为有毒中介物,导致神经元变化甚至死亡。教育缺乏的作用可能是因神经元或突触贮备不足,或使症状提前几年出现。
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页码:5 / 7+45 +45
页数:4
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