手性农药毒性评价进展

被引：44

作者：

刘维屏

张颖

机构：

[1] 浙江大学环境与资源学院环境科学研究所

来源：

浙江大学学报(农业与生命科学版) | 2012年 / 38卷 / 01期

基金：

国家杰出青年科学基金;

关键词：

手性农药; 对映体选择性; 内分泌干扰; 神经毒性; 免疫毒性; 发育毒性; 毒性机制;

D O I：

暂无

中图分类号：

S481.1 [];

学科分类号：

摘要：

长期以来,手性农药都被当作单一化合物进行环境行为和生态毒性研究,但是由于手性农药对映体与生物大分子相互作用的立体选择性,手性农药对动物及人类的毒性作用可能具有对映体选择性.本文介绍了有机磷、有机氯、拟除虫菊酯、苯基吡唑等手性农药对内分泌、神经、免疫、生殖、发育等毒性作用的对映体选择性,分析了对映体选择性产生的机制,在此基础上提出了未来的研究方向.

引用

页码：63 / 70

页数：8

共 21 条

[1]

Enantioselective induction of oxidative stress by acetofenate in rat PC12 cells.[J]..Journal of Environmental Sciences.2010, 12

[2]

Enantioselective separation and zebrafish embryo toxicity of insecticide beta-cypermethrin.[J]..Journal of Environmental Sciences.2010, 05

[3]

Understanding the endocrine disruption of chiral pesticides:The enantioselectivity in estrogenic activity of synthetic pyrethroids.[J]..Science China(Chemistry).2010, 05

[4]

DUAL ENANTIOSELECTIVE EFFECT OF THE INSECTICIDE BIFENTHRIN ON LOCOMOTOR BEHAVIOR AND DEVELOPMENT IN EMBRYONIC-LARVAL ZEBRAFISH [J].

Jin, Meiqing ;

Zhang, Ying ;

Ye, Jing ;

Huang, Changjiang ;

Zhao, Meirong ;

Le, Weiping .

ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY, 2010, 29 (07) :1561-1567

[5]

ENANTIOSELECTIVITY IN FIPRONIL AQUATIC TOXICITY AND DEGRADATION [J].

Nillos, Mae G. ;

Lin, Kunde ;

Gan, Jay ;

Bondarenko, Svetlana ;

Schlenk, Daniel .

ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY, 2009, 28 (09) :1825-1833

[6]

Enantioselectivity in aquatic toxicity of synthetic pyrethroid insecticide fenvalerate [J].

Ma, Yun ;

Chen, Linhua ;

Lu, Xianting ;

Chu, Huadong ;

Xu, Chao ;

Liu, Weiping .

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 2009, 72 (07) :1913-1918

[7]

Enantiomer-specific, bifenthrin-induced apoptosis mediated by MAPK signalling pathway in Hep G2 Cells [J].

Liu, Huigang ;

Xu, Lihong ;

Zhao, Meirong ;

Liu, Weiping ;

Zhang, Cong ;

Zhou, Shanshan .

TOXICOLOGY, 2009, 261 (03) :119-125

[8]

ENANTIOSELECTIVITY IN THE IMMUNOTOXICITY OF THE INSECTICIDE ACETOFENATE IN AN IN VITRO MODEL [J].

Zhao, Meirong ;

Liu, Weiping .

ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY, 2009, 28 (03) :578-585

[9]

ENANTIOSELECTIVE ESTROGENICITY OF o,p′-DICHLORODIPHENYLTRICHLOROETHANE IN THE MCF-7 HUMAN BREAST CARCINOMA CELL LINE [J].

Wang, Lumei ;

Zhou, Shanshan ;

Lin, Kunde ;

Zhao, Meirong ;

Liu, Weiping ;

Gan, Jianying .

ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY, 2009, 28 (01) :1-8

[10]

Enantioselective cytotoxicity of the insecticide bifenthrin on a human amnion epithelial (FL) cell line.[J].Huigang Liu;Meirong Zhao;Cong Zhang;Yun Ma;Weiping Liu.Toxicology.2008, 1

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