2型糖尿病患者血清白介素10与颈动脉粥样硬化的相关性研究

被引：7

作者：

张晓蕾

韩玲玲

尚小菁

机构：

[1] 中国医科大学附属第四医院内分泌科

来源：

中国全科医学 | 2014年 / 17卷 / 29期

关键词：

糖尿病,2型; 白细胞介素10; 动脉粥样硬化; 相关性;

D O I：

暂无

中图分类号：

R587.1 [糖尿病]; R543.4 [颈动、静脉疾病];

学科分类号：

100201 [内科学];

摘要：

目的探讨2型糖尿病(T2DM)患者血清白介素10(IL-10)与颈动脉粥样硬化的关系。方法选取2013年1—6月中国医科大学附属第四医院内分泌科收治住院的T2DM患者292例。按颈动脉内膜中层厚度(IMT)分为IMT正常组(IMT≤1.0 mm)98例、IMT增厚组(1.0 mm<IMT≤1.3 mm)101例及颈动脉粥样硬化斑块形成组(IMT>1.3 mm)93例,另选取该院体检中心体检健康者100例作为对照组。均测定血清IL-10、空腹血糖、糖化血红蛋白和IMT。结果 4组的颈动脉IMT、血清IL-10、空腹血糖、糖化血红蛋白比较,差异均有统计学意义(P<0.05)。IMT正常组、IMT增厚组、颈动脉粥样硬化斑块形成组的颈动脉IMT、空腹血糖、糖化血红蛋白均高于对照组(P<0.05);且颈动脉粥样硬化斑块形成组的空腹血糖、糖化血红蛋白高于IMT正常组(P<0.05)。IMT增厚组、颈动脉粥样硬化斑块形成组的血清IL-10低于对照组和IMT正常组(P<0.05);而IMT正常组血清IL-10与对照组比较,差异无统计学意义(P>0.05)。颈动脉IMT与血清IL-10呈负相关(r=-0.57,P<0.05);而与空腹血糖及糖化血红蛋白无直线相关性(r=-0.39、-0.42,P=0.062、0.057)。结论 T2DM患者血清IL-10与颈动脉IMT呈负相关,对颈动脉粥样硬化斑块的形成可能具有保护作用,为临床进一步研究提供了有益的参考价值。

引用

页码：3502 / 3504

页数：3

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