人体循环游离DNA应用的研究进展

被引：5

作者：

赵心亮 ^{[1
,2
]}

田广明 ^{[3
]}

田亚平 ^{[1
]}

机构：

[1] 中国人民解放军总医院生化科

[2] 北京大学医学部医学遗传系

[3] 北京大学肿瘤医院胸部肿瘤内二科

来源：

临床检验杂志 | 2013年 / 31卷 / 02期

关键词：

循环游离DNA; 肿瘤; 产前诊断;

D O I：

10.13602/j.cnki.jcls.2013.02.033

中图分类号：

R730.4 [肿瘤诊断学];

学科分类号：

100214 [肿瘤学];

摘要：

循环游离DNA(circulating cell-free DNA,ccfDNA)系存在于人及动植物体液中、在细胞外部处于游离状态的DNA分子。目前对其的研究均集中于肿瘤及妇产科学方面。本文对ccfDNA的生物学性质及在肿瘤学和妇产科学中应用的研究进展进行综述。

引用

页码：109 / 114

页数：6

共 30 条

[1]

Digital PCR Analysis of Maternal Plasma for Noninvasive Detection of Sickle Cell Anemia [J].

Barrett, Angela N. ;

McDonnell, Thomas C. R. ;

Chan, K. C. Allen ;

Chitty, Lyn S. .

CLINICAL CHEMISTRY, 2012, 58 (06) :1026-1032

[2]

Monitoring of Loss of Heterozygosity in Serum Microsatellite DNA Among Patients with Gastrointestinal Stromal Tumors Indicates Tumor Recurrence [J].

Rawnaq, Tamina ;

Schwarzenbach, Heidi ;

Schurr, Paulus G. ;

Freise, Kathrin ;

Brandl, Stephan ;

Izbicki, Jakob R. ;

Kaifi, Jussuf T. .

JOURNAL OF SURGICAL RESEARCH, 2011, 169 (01) :31-35

[3]

Noninvasive detection of fetal trisomy 21 by sequencing of DNA in maternal blood: a study in a clinical setting [J].

Ehrich, Mathias ;

Deciu, Cosmin ;

Zwiefelhofer, Tricia ;

Tynan, John A. ;

Cagasan, Lesley ;

Tim, Roger ;

Lu, Vivian ;

McCullough, Ron ;

McCarthy, Erin ;

Nygren, Anders O. H. ;

Dean, Jarrod ;

Tang, Lin ;

Hutchison, Don ;

Lu, Tim ;

Wang, Huiquan ;

Angkachatchai, Vach ;

Oeth, Paul ;

Cantor, Charles R. ;

Bombard, Allan ;

van den Boom, Dirk .

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 2011, 204 (03)

[4]

Non-invasive prenatal assessment of trisomy 21 by multiplexed maternal plasma DNA sequencing: large scale validity study.[J].Rossa W K Chiu;Ranjit Akolekar;Yama W L Zheng;Tak Y Leung;Hao Sun;K C Allen Chan;Fiona M F Lun;Attie T J I Go;Elizabeth T Lau;William W K To;Wing C Leung;Rebecca Y K Tang;Sidney K C Au-Yeung;Helena Lam;Yu Y Kung;Xiuqing Zhang;John M G van Vugt;Ryoko Minekawa;Mary H Y Tang;Jun Wang;Cees B M Oudejans;Tze K Lau;Kypros H Nicolaides;Y M Dennis Lo.BMJ: British Medical Journal.20

[5]

Clinical significance of Stratifin; ER α and PR promoter methylation in tumor and serum DNA in Indian breast cancer patients.[J].Sameer Mirza;Gayatri Sharma;Rajinder Parshad;Anurag Srivastava;Siddartha Datta Gupta;Ranju Ralhan.Clinical Biochemistry.2010, 4

[6]

Clinicopathological significance of RASSF1A reduced expression and hypermethylation in hepatocellular carcinoma [J].

Hu, Lang ;

Chen, Gang ;

Yu, Hongping ;

Qiu, Xiaoqiang .

HEPATOLOGY INTERNATIONAL, 2010, 4 (01) :423-432

[7]

Detection of PIK3CA mutations in circulating free DNA in patients with breast cancer [J].

Board, Ruth E. ;

Wardley, Andrew M. ;

Dixon, J. Michael ;

Armstrong, Anne C. ;

Howell, Sacha ;

Renshaw, Lorna ;

Donald, Emma ;

Greystoke, Alastair ;

Ranson, Malcolm ;

Hughes, Andrew ;

Dive, Caroline .

BREAST CANCER RESEARCH AND TREATMENT, 2010, 120 (02) :461-467

[8]

PCR-Based Methods for Detecting Single-Locus DNA Methylation Biomarkers in Cancer Diagnostics, Prognostics, and Response to Treatment [J].

Kristensen, Lasse Sommer ;

Hansen, Lise Lotte .

CLINICAL CHEMISTRY, 2009, 55 (08) :1471-1483

[9]

Differential Methylation Profile of Ovarian Cancer in Tissues and Plasma [J].

Melnikov, Anatoliy ;

Scholtens, Denise ;

Godwin, Andrew ;

Levenson, Victor .

JOURNAL OF MOLECULAR DIAGNOSTICS, 2009, 11 (01) :60-65

[10]

Sites of Differential DNA Methylation between Placenta and Peripheral Blood.[J].Elisavet A. Papageorgiou;Heike Fiegler;Vardhman Rakyan;Stephan Beck;Maj Hulten;Klea Lamnissou;Nigel P. Carter;Philippos C. Patsalis.The American Journal of Pathology.2009, 5

← 1 2 3 →