高迁移率族蛋白B-1与炎症关系的研究进展

被引：16

作者：

刘旺华 ^{[1
]}

李花 ^{[2
]}

肖献忠 ^{[1
]}

机构：

[1] 中南大学湘雅医学院病理生理学系

[2] 湖南中医药大学基础医学院

来源：

中国病理生理杂志 | 2008年 / 08期

关键词：

高迁移率族蛋白质类; 细胞因子类; 脓毒症;

D O I：

暂无

中图分类号：

R363 [病理生理学];

学科分类号：

摘要：

High mobility group box-1(HMGB1)distributed widely.It exists in many organs.HMGB1 locates in nuclei and cytoplasm in normal condition.It involves in many activity of life(i.e.,duplication of DNA,cellular differentiation,gene expression).The immunocytes(i.e.,mononuclear macrophage and dendritic cells)secrete HMGB1 into the extracellular milieu when stimulated with LPS and cytokines.It acts as proinflammatory cytokines,activates inflammatory and immunological responses.As a late mediators of inflammation and last long,HMGB1 plays an important role in sepsis,so it may be a convenient and practical index in evaluating severity of sepsis and may be an important and new therapeutic target in sepsis.It has been initially proved in experimental and clinical study.

引用

页码：1656 / 1660

页数：5

共 8 条

[1] 脓毒症大鼠高迁移率族蛋白-1对组织Toll样受体2基因表达的影响 [J].

姚咏明 ;

鄢小建 ;

董宁 ;

于燕 ;

陆家齐 ;

盛志勇 .

中华创伤杂志, 2003, (01) :12-15

[2] 脓毒症大鼠内毒素增敏系统改变与高迁移率族蛋白-1表达的关系 [J].

姚咏明 ;

张立天 ;

陆家齐 ;

董宁 ;

于燕 ;

鄢小建 ;

方文慧 ;

盛志勇 .

中华创伤杂志, 2002, (09) :27-30

[3] A pilot study to detect high mobility group box 1 and heat shock protein 72 in cerebrospinal fluid of pediatric patients with meningitis [J].

Tang, Daolin ;

Kang, Rui ;

Cao, Lizhi ;

Zhang, Guoyuan ;

Yu, Yan ;

Xiao, Weimin ;

Wang, Haichao ;

Xiao, Xianzhong .

CRITICAL CARE MEDICINE, 2008, 36 (01) :291-295

[4] Persistent elevation of high mobility group box-1 protein (HMGB1) in patients with severe sepsis and septic shock [J].

Sundén-Cullberg, J ;

Norrby-Teglund, A ;

Rouhiainen, A ;

Rauvala, H ;

Herman, G ;

Tracey, KJ ;

Lee, ML ;

Andersson, J ;

Tokics, L ;

Treutiger, CJ .

CRITICAL CARE MEDICINE, 2005, 33 (03) :564-573

[5] RAGE is the major receptor for the proinflammatory activity of HMGB1 in rodent macrophages [J].

Kokkola, R ;

Andersson, Å ;

Mullins, G ;

Östberg, T ;

Treutiger, CJ ;

Arnold, B ;

Nawroth, P ;

Andersson, U ;

Harris, RA ;

Harris, HE .

SCANDINAVIAN JOURNAL OF IMMUNOLOGY, 2005, 61 (01) :1-9

[6]

Kevin A. O'Connor,Michael K. Hansen,C. Rachal Pugh,Molly M. Deak,Joseph C. Biedenkapp,Erin D. Milligan,John D. Johnson,Haichao Wang,Steven F. Maier,Kevin J. Tracey,Linda R. Watkins.Further characterization of high mobility group box 1 (HMGB1) as a proinflammatory cytokine: central nervous system effects[J].Cytokine,2003(6)

[7] The gesture life of high mobility group box 1 [J].

Friedman, SG ;

Czura, CJ ;

Tracey, KJ .

CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE, 2003, 6 (03) :283-287

[8] HMGB-1, a DNA-binding protein with cytokine activity, induces brain TNF and IL-6 production, and mediates anorexia and taste aversion [J].

Agnello, D ;

Wang, HC ;

Yang, H ;

Tracey, KJ ;

Ghezzi, P .

CYTOKINE, 2002, 18 (04) :231-236

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