铁过载对绝经后骨质疏松患者骨密度和骨代谢的影响

被引：22

作者：

林琳 ^{[1
]}

林安平 ^{[2
]}

机构：

[1] 重庆两江新区第一人民医院妇产科

[2] 重庆医科大学附属第二医院妇科

来源：

中国骨质疏松杂志 | 2019年 / 25卷 / 12期

关键词：

铁过载; 绝经后妇女; 骨质疏松症; 骨量减少; 骨代谢; 骨密度;

D O I：

暂无

中图分类号：

R580 [];

学科分类号：

摘要：

目的观察铁过载对绝经后骨质疏松患者骨密度和骨代谢的影响。方法将234名绝经后妇女按照骨密度(bone mineral density, BMD)分为正常组、骨量减少组和骨质疏松组。分析铁过载对年龄、绝经年数、血钙(Ca)、磷(P)、体质量指数(bone mass index,BMI)、肝肾功能、葡萄糖代谢、脂质代谢、炎症反应、BMD、抗酒石酸酸性磷酸酶5b(TRACP-5b)、ALP、Ⅰ型胶原交联C端肽(β-CTX)和Ⅰ型胶原交联N端肽(PINP)的影响。结果与正常组相比,骨量减少组和骨质疏松组血清铁蛋白(Fer)显著升高(P<0.05)。Fer水平与BMD呈负相关(P<0.05)。TRACP-5b水平在骨质疏松组明显高于正常组(P<0.05)。与正常组相比,骨质疏松症组的ALP水平显著升高(P<0.05)。与骨量减少组相比,骨质疏松组血清β-CTX水平明显升高(P<0.05);且骨质疏松组的PINP水平显著高于正常组(P<0.05)。更重要的是,血清Fer和PINP之间存在正相关(P<0.05);血清Fer和β-CTX之间呈正相关(P<0.05)。结论铁过载对绝经后骨质疏松患者骨密度和骨代谢均有显著影响。

引用

页码：1747 / 1750

页数：4

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