一个新的细胞死亡形式:Parthanatos

被引:5
作者
王连邦
张丽英
单春华
机构
[1] 东北林业大学生命科学学院发育生物学研究室
关键词
Parthanatos; 多聚ADP核糖聚合酶-1; 多聚ADP核糖; 凋亡诱导因子; 细胞死亡;
D O I
暂无
中图分类号
Q255 [细胞的衰老与死亡];
学科分类号
摘要
Parthanatos是发生在中风、帕金森氏病、心力衰竭、糖尿病以及缺血再灌注损伤等疾病中的一种细胞死亡。该死亡是由兴奋性中毒引起的DNA损伤,进一步导致PARP-1激活而引发的细胞死亡,又称为PARP-1依赖性细胞死亡。目前关于Parthanatos的研究还处于初期阶段,对其信号通路的分子机制说法还不统一。文章就Parthanatos分子机制的研究进展进行了综述。
引用
收藏
页码:881 / 885
页数:5
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