大黄素诱导肝癌细胞氧化损伤的实验研究

被引：7

作者：

荆绪斌

李涛

机构：

[1] 汕头大学医学院第一附属医院消化内科

[2] 汕头大学医学院第一附属医院消化内科汕头市

[3] 汕头市

来源：

胃肠病学和肝病学杂志 | 2002年 / 03期

关键词：

大黄素; 活性氧; 肝癌细胞;

D O I：

暂无

中图分类号：

R735.7 [肝肿瘤];

学科分类号：

100214 ;

摘要：

目的　研究大黄素抑制肝癌细胞增殖的作用机理。方法　采用流式细胞仪法观察了大黄素对肝癌细胞内活性氧的影响 ;采用MTT比色法观察了大黄素对细胞增殖的影响。结果　大黄素作用于肝癌细胞后 ,在 2小时内引起活性氧的产生 ;大黄素抑制了肝癌细胞的增殖。结论　大黄素能够通过诱导细胞内活性氧的产生 ,引起细胞脂质过氧化 ,抑制了肝癌细胞的增殖。

引用

页码：219 / 221

页数：3

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