骨关节炎软骨退变基因调控的研究进展

被引：20

作者：

杜国庆 ^{[1
,2
]}

丁道芳 ^{[1
,2
]}

李玲慧 ^{[1
,2
]}

宋奕 ^{[3
]}

王辉昊 ^{[1
,2
]}

詹红生 ^{[1
,2
]}

机构：

[1] 上海中医药大学附属曙光医院石氏伤科医学中心

[2] 上海市中医药研究院骨伤科研究所

[3] 上海中医药大学

来源：

中国矫形外科杂志 | 2013年 / 21卷 / 11期

关键词：

骨关节炎; 软骨退变; 基因调控;

D O I：

暂无

中图分类号：

R684.3 [关节炎];

学科分类号：

100220 [骨科学];

摘要：

<正>骨关节炎是一种最常见的关节病变,该病不仅发生关节软骨损害,还累及整个关节,包括软骨下骨、韧带、关节囊、滑膜和关节周围肌肉,最终发生关节软骨退变、纤维化、断裂、溃疡及整个关节面的损害。骨关节炎发病以中老年居多,目前我国60岁以上

引用

页码：1089 / 1093

页数：5

共 13 条

[1]

Inhibition of cathepsin K reduces cartilage degeneration in the anterior cruciate ligament transection rabbit and murine models of osteoarthritis [J].

Hayami, Tadashi ;

Zhuo, Ya ;

Wesolowski, Gregg A. ;

Pickarski, Maureen ;

Duong, Le T. .

BONE, 2012, 50 (06) :1250-1259

[2]

Bone Morphogenetic Proteins and articular cartilage.[J].P.M. van der Kraan;E.N. Blaney Davidson;W.B. van den Berg.Osteoarthritis and Cartilage.2010, 6

[3]

Chondrocyte hypertrophy can be induced by a cryptic sequence of type II collagen and is accompanied by the induction of MMP-13 and collagenase activity: Implications for development and arthritis [J].

Tchetina, Elena V. ;

Kobayashi, Masahiko ;

Yasuda, Tadashi ;

Meijers, Tineke ;

Pidoux, Isabelle ;

Poole, A. Robin .

MATRIX BIOLOGY, 2007, 26 (04) :247-258

[4]

Wnt induction of chondrocyte hypertrophy through the Runx2 transcription factor [J].

Dong, Yu-Feng ;

Soung, Do Y. ;

Schwarz, Edward M. ;

O'Keefe, Regis J. ;

Drissi, Hicham .

JOURNAL OF CELLULAR PHYSIOLOGY, 2006, 208 (01) :77-86

[5]

The role of cathepsins in osteoporosis and arthritis:: Rationale for the design of new therapeutics [J].

Yasuda, Y ;

Kaleta, J ;

Brömme, D .

ADVANCED DRUG DELIVERY REVIEWS, 2005, 57 (07) :973-993

[6]

Hip dysplasia and osteoarthrosis.[J].Steffen Jacobsen;Stig Sonne-holm;Kjeld Søballe;Peter Gebuhr;Bjarne Lund.Acta Orthopaedica.2005, 2

[7]

Interaction of FGF; Ihh/Pthlh; and BMP Signaling Integrates Chondrocyte Proliferation and Hypertrophic Differentiation.[J].Eleonora Minina;Conny Kreschel;Michael C. Naski;David M. Ornitz;Andrea Vortkamp.Developmental Cell.2002, 3

[8]

Inhibition of growth plate angiogenesis and endochondral ossification with diminished expression of MMP-13 in hypertrophic chondrocytes in FGF-2-treated rats [J].