阿托伐他汀对老年冠心病患者内皮依赖性血管舒张功能及脉搏波速度的影响

被引：9

作者：

杜孝芝 ^{[1
]}

黎莉 ^{[1
]}

王秀荣 ^{[2
]}

王媛媛 ^{[1
]}

蒋桂花 ^{[1
]}

机构：

[1] 山东大学齐鲁医院心血管内科教育部和卫生部心血管重构和功能研究重点实验室

[2] 济南市槐荫区人民医院急诊科

来源：

中国老年学杂志 | 2009年 / 29卷 / 19期

关键词：

冠心病; 动脉硬化; 阿托伐他汀; 内皮依赖性血管舒张功能; 脉搏波速度;

D O I：

暂无

中图分类号：

R541.4 [冠状动脉（粥样）硬化性心脏病（冠心病）];

学科分类号：

1002 ; 100201 ;

摘要：

目的探讨冠心病患者服用阿托伐他汀1年肱动脉内皮依赖性血管舒张功能(FMD)及脉搏波速度(PWV)的影响。方法选取35例(≥60岁)长期服用阿托伐他汀的冠心病患者作为阿托伐他汀组,选取25例(≥60岁)从未用过调脂药物的冠心病患者作为未服用阿托伐他汀组,20例(<60岁)健康人作健康对照组,阿托伐他汀组在常规治疗的基础上,服用阿托伐他汀10mg,1次/d,睡前口服,治疗1年。治疗前后用高频超声和科林VP-1000检查FMD及PWV,同时测血脂。结果阿托伐他汀组治疗后与治疗前及未服用阿托伐他汀组相比FMD(P<0.05),PWV(P<0.05)及血脂(P<0.05)均明显改善。结论冠心病患者应用阿托伐他汀不仅可以调脂,还可以改善FMD及PWV,从而改善动脉弹性。

引用

页码：2427 / 2429

页数：3

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