川芎嗪、丹参酮ⅡA对PG干细胞样细胞凋亡的影响

被引：2

作者：

王耀焓

张培彤

杨栋

韩海英

郭秀伟

祁鑫

张芸

机构：

[1] 中国中医科学院广安门医院肿瘤科

来源：

辽宁中医杂志 | 2016年 / 43卷 / 05期

关键词：

肿瘤干细胞; 凋亡; 川芎嗪; 丹参酮ⅡA;

D O I：

10.13192/j.issn.1000-1719.2016.05.045

中图分类号：

R285 [中药药理学];

学科分类号：

100806 [中药药理学];

摘要：

目的:观察不同剂量川芎嗪、丹参酮ⅡA对干细胞样细胞凋亡的影响。方法:将无血清培养获得的球细胞随机分为7组,依次为对照组、低剂量川芎嗪组、中剂量川芎嗪组、高剂量川芎嗪组、低剂量丹参酮ⅡA组、中剂量丹参酮ⅡA组、高剂量丹参酮ⅡA组,应用流式细胞术分别检测PG-BE1、PG-LH7细胞凋亡。结果:PG-BE1细胞系中剂量川芎嗪及不同浓度丹参酮ⅡA均可促进PG-BE1干细胞样细胞凋亡,其中高剂量丹参酮ⅡA促凋亡作用最强,其余三组之间促凋亡能力无统计学差异;PG-LH71细胞系低、高浓度川芎嗪、丹参酮ⅡA对PG干细胞样细胞均有促凋亡作用,其中高剂量丹参酮ⅡA促凋亡能力最强,低剂量川芎嗪促凋亡能力最弱。结论:无论是PG-BE1细胞系还是PG-LH7细胞系,高剂量丹参酮ⅡA均可明显促进PG干细胞样细胞的凋亡,其促凋亡能力等于或大于顺铂促凋亡能力。

引用

页码：1024 / 1028+4 +4-5

页数：7

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