山东省某地区精神分裂症患者6号染色体的基因组扫描研究

被引：16

作者：

朱海宁

陈刚

温晓燕

林汝湘

朱建平

魏然

周鹏

栾萌

于锡巧

刘文敏

高春义

翁正

机构：

[1] 山东省医学科学院基础医学研究所现代医用药物与技术重点实验室

[2] 潍坊市第三人民医院精神科

[3] 山东省精神卫生中心防治科

来源：

中华精神科杂志 | 2007年 / 40卷 / 02期

关键词：

精神分裂症; 染色体,人; 遗传; 基因组; 基因池;

D O I：

暂无

中图分类号：

R749.3 [精神分裂症];

学科分类号：

100204 [神经病学];

摘要：

目的在6号染色体上寻找与精神分裂症的关联区域,进而定位精神分裂症的致病基因。方法在6号染色体采用间隔10 cM(厘摩)遗传距离的20个微卫星遗传标记,分别对山东省潍坊市东部地区119例精神分裂症患者和119名正常对照者的 DNA 混合样本进行基因组扫描,比较两组每个等位基因峰值比率的差异。结果患者组 D6S289和 D6S460两个遗传位点上的等位基因频率分别为0.121和0.200,高于对照组(分别为0.046和0.157,P<0.01),而患者组 D6S1610遗传位点的等位基因频率(0.087)低于对照组(0.161,P<0.01)。结论山东省潍坊市东部地区的精神分裂症患者中存在与6号染色体的关联区域,致病因子(基因或调控因子等)可能位于其中。

引用

页码：82 / 85

页数：4

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