血清颗粒蛋白前体在慢性阻塞性肺疾病患者病情及预后评估中的价值

被引：6

作者：

卞淼 ^{[1
]}

安莲华 ^{[2
]}

逄利 ^{[2
]}

机构：

[1] 吉林省前卫医院呼吸内科

[2] 吉林大学第一医院

来源：

中国老年学杂志 | 2016年 / 36卷 / 13期

关键词：

慢性阻塞性肺疾病; 颗粒蛋白前体;

D O I：

暂无

中图分类号：

R563.9 [其他];

学科分类号：

100201 [内科学];

摘要：

目的探讨血清颗粒蛋白前体(PGRN)对慢性阻塞性肺疾病(COPD)患者病情评估及预后的判断价值。方法选取COPD急性加重期患者38例(AECOPD组)、COPD稳定期患者32例(SCOPD组)及同期健康对照者30例(对照组)。入院后24 h内采用酶联免疫吸附法测定血清PGRN浓度。追踪AECOPD患者到入院28 d后,根据转归分为死亡组和存活组。比较各组血清PGRN的差异,分析PGRN与COPD严重程度及AECOPD患者28 d病死率的关系。结果 AECOPD组及SCOPD组血清PGRN水平明显高于对照组;AECOPD组水平高于SCOPD组;死亡组明显高于存活组。受试者工作特征曲线显示血清PGRN诊断AECOPD及预测AECOPD患者28 d病死率均具有较高的灵敏度和特异度。结论血清PGRN可作为评估COPD患者病情严重程度及预后的重要指标。

引用

页码：3228 / 3230

页数：3

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