嗜酸粒细胞在气道激活机制中的研究进展

被引：8

作者：

邵婧昕

汪慧英

机构：

[1] 浙江大学医学院附属二院变态反应科

来源：

中华哮喘杂志(电子版) | 2011年 / 5卷 / 01期

关键词：

嗜酸粒细胞; 支气管哮喘; 气道; 激活机制;

D O I：

暂无

中图分类号：

R562.25 [];

学科分类号：

摘要：

支气管哮喘是一种以嗜酸粒细胞(eosinophils,EOS)和肥大细胞浸润、气道高反应性为主要病理生理特征的慢性气道炎症,其中EOS在气道的激活对疾病的发生发展起着关键作用。气道中的EOS主要来源于外周血,极小部分来源于气道内的嗜酸粒细胞前体祖细胞,前者早在外周血中便在内皮细胞的作用下开始启动激活,之后气道上皮细胞通过表达细胞因子IL-3、IL-6、IL-8、RANTES及EOS重要的趋化因子eotaxin等趋化其向气道迁移。两种来源的EOS在气道的激活都是各种炎症细胞、细胞因子、趋化因子相互作用的结果 :一方面,气道内的Th2细胞、Th1细胞、Th17细胞、肥大细胞等通过分泌IL-4、IL-5、IL-17等细胞因子促进EOS的激活;另一方面,各种细胞因子如PAF、IL-33、IL-7等也通过各种途径激活EOS并维持EOS的活性。本文就目前国内外关于EOS在气道激活机制的研究情况作一综述。

引用

页码：49 / 54

页数：6

共 7 条

[1]

Allergen-induced, eotaxin-rich, proangiogenic bone marrow progenitors: A blood-borne cellular envoy for lung eosinophilia [J].

Asosingh, Kewal ;

Hanson, Jodi D. ;

Cheng, Georgiana ;

Aronica, Mark A. ;

Erzurum, Serpil C. .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2010, 125 (04) :918-925

[2]

Modulation by Flunisolide of Tumor Necrosis Factor-α–Induced Stimulation of Airway Epithelial Cell Activities Related to Eosinophil Inflammation.[J].S. Boero;M. Silvestri;N. Ullmann;G. A. Rossi.Journal of Asthma.2010, 4

[3]

IL-4 alters expression patterns of storage components of vascular endothelial cell-specific granules through STAT6-and SOCS-1-dependent mechanisms [J].

Inomata, Megumi ;

Into, Takeshi ;

Nakashima, Misako ;

Noguchi, Toshihide ;

Matsushita, Kenji .

MOLECULAR IMMUNOLOGY, 2009, 46 (10) :2080-2089

[4]

TP receptor-mediated release of eosinophil chemotactic activity from human bronchial smooth muscle cells.[J].Yusuke Suzuki;Koichiro Asano;Kyoko Niimi;Jun Miyata;Yoshiki Shiraishi;Koichi Fukunaga;Tetsuya Shiomi;Takeshi Nakajima;Tsuyoshi Oguma;Koichi Sayama;Akitoshi Ishizaka.European Journal of Pharmacology.2008, 1

[5]

CC chemokines and transmigration of eosinophils in the presence of vascular cell adhesion molecule 1 [J].

Yamamoto, H ;

Nagata, M ;

Sakamoto, Y .

ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY, 2005, 94 (02) :292-300

[6]

Effects of the very late adhesion molecule 4 antagonist WAY103 on human peripheral blood eosinophil vascular cell adhesion molecule 1–dependent functions.[J].Julie B. Sedgwick;Kristyn J. Jansen;Jeffrey D. Kennedy;Hirohito Kita;William W. Busse.The Journal of Allergy and Clinical Immunology.2005, 4

[7]

Progenitor egress from the bone marrow after allergen challenge: Role of stromal cell–derived factor 1α and eotaxin.[J].Sandra C. Dorman;Irene Babirad;Julia Post;Rick M. Watson;Ronan Foley;Graham L. Jones;Paul M. O'Byrne;Roma Sehmi.The Journal of Allergy and Clinical Immunology.2005, 3

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