星形胶质细胞调节慢性疼痛的分子机制

被引：64

作者：

高永静 ^{[1
]}

纪如荣 ^{[2
]}

机构：

[1] 南通大学航海医学研究所疼痛研究室

[2] 美国杜克大学医学院麻醉系

来源：

中国疼痛医学杂志 | 2013年 / 19卷 / 09期

关键词：

星形胶质细胞; 慢性疼痛; 神经炎症反应; 趋化因子; 细胞因子; 神经元-胶质细胞相互作用; 脊髓;

D O I：

暂无

中图分类号：

R402 [];

学科分类号：

摘要：

慢性疼痛是临床治疗上的难题之一,开发新的镇痛药物需要对慢性疼痛的产生和维持机制进行更加深入的研究。近年来的研究表明,神经胶质细胞,尤其是中枢神经系统的小胶质细胞和星形胶质细胞在慢性疼痛的发生发展中起重要作用。星形胶质细胞是中枢神经系统中数量最多、占据体积最大的细胞,在结构上与神经元突触紧密接触。而且,外周神经损伤、组织损伤、肿瘤浸润、关节炎等引起的慢性疼痛状态下,脊髓星形胶质细胞比小胶质细胞呈现出更持久的活化,该活化与慢性疼痛行为密切相关。活化的星形胶质细胞可通过丝裂原激活的蛋白激酶/MAP激酶(MAPK)释放炎症前细胞因子、趋化因子等调节神经元的兴奋性,促进慢性疼痛的维持。本文对脊髓星形胶质细胞参与慢性疼痛调节的机制研究进展进行了综述。

引用

页码：545 / 552

页数：8

共 21 条

[1]

Chemokine contribution to neuropathic pain: Respective induction of CXCL1 and CXCR2 in spinal cord astrocytes and neurons [J].

Zhang, Zhi-Jun ;

Cao, De-Li ;

Zhang, Xin ;

Ji, Ru-Rong ;

Gao, Yong-Jing .

PAIN, 2013, 154 (10) :2185-2197

[2]

Astrocytic CX43 hemichannels and gap junctions play a crucial role in development of chronic neuropathic pain following spinal cord injury [J].

Chen, Michael J. ;

Kress, Benjamin ;

Han, Xiaoning ;

Moll, Katherine ;

Peng, Weiguo ;

Ji, Ru-Rong ;

Nedergaard, Maiken .

GLIA, 2012, 60 (11) :1660-1670

[3]

Thrombospondin-4 Contributes to Spinal Sensitization and Neuropathic Pain States [J].

Kim, Doo-Sik ;

Li, Kang-Wu ;

Boroujerdi, Amin ;

Yu, Yanhui Peter ;

Zhou, Chun-Yi ;

Deng, Ping ;

Park, John ;

Zhang, Xia ;

Lee, Joshua ;

Corpe, Michael ;

Sharp, Kelli ;

Steward, Oswald ;

Eroglu, Cagla ;

Barres, Ben ;

Zaucke, Frank ;

Xu, Zao C. ;

Luo, Z. David .

JOURNAL OF NEUROSCIENCE, 2012, 32 (26) :8977-8987

[4]

Neuronal NR2B-containing NMDA receptor mediates spinal astrocytic c-Jun N-terminal kinase activation in a rat model of neuropathic pain [J].

Wang, Wei ;

Mei, Xiao-Peng ;

Wei, Yan-Yan ;

Zhang, Ming-Ming ;

Zhang, Ting ;

Wang, Wen ;

Xu, Li-Xian ;

Wu, Sheng-Xi ;

Li, Yun-Qing .

BRAIN BEHAVIOR AND IMMUNITY, 2011, 25 (07) :1355-1366

[5]

Spinal Injection of TNF-α-activated Astrocytes Produces Persistent Pain Symptom Mechanical Allodynia by Releasing Monocyte Chemoattractant Protein-1 [J].

Gao, Yong-Jing ;

Zhang, Ling ;

Ji, Ru-Rong .

GLIA, 2010, 58 (15) :1871-1880

[6]

Targeting Astrocyte Signaling for Chronic Pain [J].

Gao, Yong-Jing ;

Ji, Ru-Rong .

NEUROTHERAPEUTICS, 2010, 7 (04) :482-493

[7]

Chemokines; neuronal–glial interactions; and central processing of neuropathic pain.[J].Yong-Jing Gao;Ru-Rong Ji.Pharmacology and Therapeutics.2010, 1

[8]

Gabapentin Receptor α2δ-1 Is a Neuronal Thrombospondin Receptor Responsible for Excitatory CNS Synaptogenesis [J].

Eroglu, Cagla ;

Allen, Nicola J. ;

Susman, Michael W. ;

O'Rourke, Nancy A. ;

Park, Chan Young ;

Oezkan, Engin ;

Chakraborty, Chandrani ;

Mulinyawe, Sara B. ;

Annis, Douglas S. ;

Huberman, Andrew D. ;

Green, Eric M. ;

Lawler, Jack ;

Dolmetsch, Ricardo ;

Garcia, K. Christopher ;

Smith, Stephen J. ;

Luo, Z. David ;

Rosenthal, Arnon ;

Mosher, Deane F. ;

Barres, Ben A. .

CELL, 2009, 139 (02) :380-392

[9]

Selective inhibition of JNK with a peptide inhibitor attenuates pain hypersensitivity and tumor growth in a mouse skin cancer pain model [J].

Gao, Yong-Jing ;

Cheng, Jen-Kun ;

Zeng, Qing ;

Xu, Zhen-Zhong ;

Decosterd, Isabelle ;

Xu, Xiaoyin ;

Ji, Ru-Rong .

EXPERIMENTAL NEUROLOGY, 2009, 219 (01) :146-155

[10]

Spinal astrocyte and microglial activation contributes to rat pain-related behaviors induced by the venom of scorpion Buthus martensi Karch.[J].Feng Jiang;Tong Liu;Ming Cheng;Xue-Yan Pang;Zhan-Tao Bai;Jing-Jing Zhou;Yong-Hua Ji.European Journal of Pharmacology.2009, 1

← 1 2 3 →