法尼醇X受体在原发性胆汁性胆管炎治疗中的作用

被引：6

作者：

赵健

李伟

姚定康

机构：

[1] 第二军医大学附属长征医院内科教研室

来源：

胃肠病学 | 2017年 / 22卷 / 02期

关键词：

原发性胆汁性胆管炎; 法尼醇X受体; 奥贝胆酸; 胆酸; 治疗;

D O I：

暂无

中图分类号：

R575.7 [胆管疾病];

学科分类号：

100201 [内科学];

摘要：

原发性胆汁性胆管炎(PBC)是一种常见的胆汁淤积性肝病。熊去氧胆酸(UDCA)是目前惟一被批准并能有效治疗PBC的药物,但高达40%的PBC患者对UDCA应答不佳。法尼醇X受体(FXR)具有抑制胆汁酸合成、调控胆汁酸转运和抗肝纤维化的作用。本文就FXR在PBC治疗中的作用作一综述。

引用

页码：109 / 111

页数：3

共 18 条

[1]

Agonist of farnesoid X receptor protects against bile acid induced damage and oxidative stress in mouse placenta – A study on maternal cholestasis model.[J].W.-B. Wu;Y.-Y. Xu;W.-W. Cheng;Y.-X. Wang;Y. Liu;D. Huang;H.-J. Zhang.Placenta.2015, 5

[2]

657 The First New Trials for Primary Biliary Cirrhosis in a Decade: An International Program Evaluating the Farnesoid X Receptor Agonist Obeticholic Acid.[J].Kris Kowdley;Frederik Nevens;Pietro Andreone;Velimir A. Luketic;Hemant Shah;Richard Pencek;Tonya K. Marmon;David Shapiro.Gastroenterology.2015, 4S1

[3]

Efficacy of Obeticholic Acid in Patients With Primary Biliary Cirrhosis and Inadequate Response to Ursodeoxycholic Acid [J].

Hirschfield, Gideon M. ;

Mason, Andrew ;

Luketic, Velimir ;

Lindor, Keith ;

Gordon, Stuart C. ;

Mayo, Marlyn ;

Kowdley, Kris V. ;

Vincent, Catherine ;

Bodhenheimer, Henry C., Jr. ;

Pares, Albert ;

Trauner, Michael ;

Marschall, Hanns-Ulrich ;

Adorini, Luciano ;

Sciacca, Cathi ;

Beecher-Jones, Tessa ;

Castelloe, Erin ;

Boehm, Olaf ;

Shapiro, David .

GASTROENTEROLOGY, 2015, 148 (04) :751-U347

[4]

Targeting FXR in cholestasis: hype or hope [J].

Fiorucci, Stefano ;

Distrutti, Eleonora ;

Ricci, Patrizia ;

Giuliano, Vittorio ;

Donini, Annibale ;

Baldelli, Franco .

EXPERT OPINION ON THERAPEUTIC TARGETS, 2014, 18 (12) :1449-1459

[5]

Levels of Alkaline Phosphatase and Bilirubin Are Surrogate End Points of Outcomes of Patients With Primary Biliary Cirrhosis: An International Follow-up Study [J].

Lammers, Willem J. ;

van Buuren, Henk R. ;

Hirschfield, Gideon M. ;

Janssen, Harry L. A. ;

Invernizzi, Pietro ;

Mason, Andrew L. ;

Ponsioen, Cyriel Y. ;

Floreani, Annarosa ;

Corpechot, Christophe ;

Mayo, Marlyn J. ;

Battezzati, Pier M. ;

Pares, Albert ;

Nevens, Frederik ;

Burroughs, Andrew K. ;

Kowdley, Kris V. ;

Trivedi, Palak J. ;

Kumagi, Teru ;

Cheung, Angela ;

Lleo, Ana ;

Imam, Mohamad H. ;

Boonstra, Kirsten ;

Cazzagon, Nora ;

Franceschet, Irene ;

Poupon, Raoul ;

Caballeria, Llorenc ;

Pieri, Giulia ;

Kanwar, Pushpjeet S. ;

Lindor, Keith D. ;

Hansen, Bettina E. .

GASTROENTEROLOGY, 2014, 147 (06) :1338-+

[6]

Bile Acid Derivatives as Ligands of the Farnesoid X Receptor: Molecular Determinants for Bile Acid Binding and Receptor Modulation [J].

Gioiello, Antimo ;

Cerra, Bruno ;

Mostarda, Serena ;

Guercini, Chiara ;

Pellicciari, Roberto ;

Macchiarulo, Antonio .

CURRENT TOPICS IN MEDICINAL CHEMISTRY, 2014, 14 (19) :2159-2174

[7]

The diagnosis of primary biliary cirrhosis [J].

Bowlus, Christopher L. ;

Gershwin, M. Eric .

AUTOIMMUNITY REVIEWS, 2014, 13 (4-5) :441-444

[8]

E297G mutated bile salt export pump (BSEP) function enhancers derived from GW4064: Structural development study and separation from farnesoid X receptor-agonistic activity [J].

Misawa, Takashi ;

Hayashi, Hisamitsu ;

Makishima, Makoto ;

Sugiyama, Yuichi ;

Hashimoto, Yuichi .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2012, 22 (12) :3962-3966

[9]

964 THE FARNESOID X RECEPTOR (FXR) AGONIST OBETICHOLIC ACID (OCA) INCREASES PLASMA FGF-19 CONCENTRATIONS AND DECREASES BILE ACID SYNTHESIS IN PRIMARY BILIARY CIRRHOSIS (PBC).[J].H.-U. Marschall;V. Luketic;A. Lovgren-Sandblom;L. Benthin;K. Kowdley;G. Hirschfield;A. Mason;K. Lindor;S. Gordon;C. Vincent;R. Chapman;M. Mayo;A. Burroughs;A. Pares;D. Jones;C. Schramm;L. Eliot;A.F. Hofmann;D. Shapiro.Journal of Hepatology.2012,

[10]

952 LONG-TERM (LT) THERAPY OF A FARNESOID X RECEPTOR (FXR) AGONIST OBETICHOLIC ACID (OCA) MAINTAINS BIOCHEMICAL RESPONSE IN PRIMARY BILIARY CIRRHOSIS (PBC).[J].G. Hirschfield;K. Kowdley;A. Mason;V. Luketic;S. Gordon;C. Vincent;M. Mayo;A. Pares;R. Chapman;K. Lindor;M. Esguerra;L. Eliot;D. Shapiro.Journal of Hepatology.2012,

← 1 2 →