寡核苷酸配基在临床诊断和疾病治疗中的应用

被引:3
作者
王成龙
机构
[1] 军事医学科学院基础医学研究所北京中国人民解放军总医院北京
关键词
寡核苷酸配基; 蛋白功能阻断剂; 靶向剂;
D O I
10.13220/j.cnki.jipr.2003.04.009
中图分类号
R96 [药理学];
学科分类号
100602 ; 100706 ;
摘要
利用指数级富集的配基进化 (SELEX)技术筛选得到的寡核苷酸配基与靶分子的结合具有亲和力高、特异性强的特点 ,在临床诊断和疾病治疗中具有一定的优势 ,有可能发展成为一类新型药物和诊断试剂。本文从配基的筛选和改造 ,配基作为蛋白功能阻断剂、靶向剂和体外诊断试剂的应用和配基在应用中可能存在的问题等几个方面 ,对用SELEX技术筛选的寡核苷酸配基在临床诊断和疾病治疗中的应用进行综述
引用
收藏
页码:223 / 228
页数:6
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