内皮细胞凋亡与动脉粥样硬化关系的研究进展

被引：18

作者：

李蓉 ^{[1
,2
]}

蔡辉 ^{[1
,2
]}

机构：

[1] 南方医科大学南京临床医学院

[2] 南京军区南京总医院

来源：

中国老年学杂志 | 2012年 / 32卷 / 12期

基金：

中国博士后科学基金;

关键词：

内皮细胞; 凋亡; 动脉粥样硬化;

D O I：

暂无

中图分类号：

R543.5 [动脉疾病];

学科分类号：

1002 ; 100201 ;

摘要：

<正>血管内皮细胞(ECs)是紧贴血管壁的单层细胞,在血管稳态平衡中有重要作用,易受到炎性细胞和循环因子损害,诱导ECs活化和损伤。动脉粥样硬化(AS)与ECs之间关系密切,ECs损伤是AS形成的早期始动环节,并有实验发现在粥样斑块中ECs、平滑肌细胞和免疫细胞凋亡现象增加,覆盖于血管病变处的ECs促凋亡蛋白如Fas和Bax表达升高,抗凋亡因子

引用

页码：2649 / 2652

页数：4

共 18 条

[1] The induction of reactive oxygen species and loss of mitochondrial Omi/HtrA2 is associated with S-nitrosoglutathione-induced apoptosis in human endothelial cells [J].

Liu, Qi-bing ;

Liu, Lu-lu ;

Lu, Ying-mei ;

Tao, Rong-rong ;

Huang, Ji-yun ;

Shioda, Norifumi ;

Moriguchi, Shigeki ;

Fukunaga, Kohji ;

Han, Feng ;

Lou, Yi-jia .

TOXICOLOGY AND APPLIED PHARMACOLOGY, 2010, 244 (03) :374-384

[2]

Mediation of Electronegative Low-Density Lipoprotein Signaling by LOX-1: A Possible Mechanism of Endothelial Apoptosis[J] . Jonathan Lu,Jun-Hai Yang,Alan R. Burns,Hsin-Hung Chen,Daming Tang,Jeffrey P. Walterscheid,Shinichi Suzuki,Chao-Yuh Yang,Tatsuya Sawamura,Chu-Huang Chen.Circulation Research . 2009 (5)

[3]

Endothelial Dysfunction Caused by Circulating Microparticles from Patients with Metabolic Syndrome[J] . Abdelali Agouni,Anne Hélène Lagrue-Lak-Hal,Pierre Henri Ducluzeau,Hadj Ahmed Mostefai,Catherine Draunet-Busson,Georges Leftheriotis,Christophe Heymes,Maria Carmen Martinez,Ramaroson Andriantsitohaina.The American Journal of Pathology . 2008 (4)

[4]

X-Linked Inhibitor of Apoptosis Protein Is an Important Regulator of Vascular Endothelial Growth Factor–Dependent Bovine Aortic Endothelial Cell Survival[J] . Jongmin Kim,Jongbong Park,Seungmin Choi,Sung-Gil Chi,Amy L. Mowbray,Hanjoong Jo,Heonyong Park.Circulation Research . 2008 (8)

[5]

Differences in the Effect of Angiotensin-converting Enzyme Inhibitors on the Rate of Endothelial Cell Apoptosis: In Vitro and In Vivo Studies[J] . C. Ceconi,G. Francolini,D. Bastianon,G.L. Gitti,L. Comini,R. Ferrari.Cardiovascular Drugs and Therapy . 2007 (6)

[6]

Oxidized low density lipoprotein receptor-1 mediates oxidized low density lipoprotein-induced apoptosis in human umbilical vein endothelial cells: Role of reactive oxygen species[J] . Xiu-ping Chen,Ke-li Xun,Qin Wu,Tian-tai Zhang,Jing-shan Shi,Guan-hua Du.Vascular Pharmacology . 2007 (1)

[7]

Understanding endothelial cell apoptosis: what can the transcriptome, glycome and proteome reveal?[J] . Affara Muna,Dunmore Benjamin,Savoie Christopher,Imoto Seiya,Tamada Yoshinori,Araki Hiromitsu,Charnock-Jones D. Stephen,Miyano Satoru,Print Cristin.Philosophical Transactions of The Royal Society B . 2007 (1484)

[8] Hyperglycemia and reactive oxygen species mediate apoptosis in aortic endothelial cells through Janus kinase 2 [J].

Tawfik, A ;

Jin, LM ;

Banes-Berceli, AKL ;

Caldwell, RB ;

Ogbi, S ;

Shirley, A ;

Barber, D ;

Catravas, JD ;

Stern, DM ;

Fulton, D ;

Caldwell, RW ;

Marrero, MB .

VASCULAR PHARMACOLOGY, 2005, 43 (05) :320-326

[9] Low doses of reactive oxygen species protect endothelial cells from apoptosis by increasing thioredoxin-1 expression [J].

Haendeler, J ;

Tischler, V ;

Hoffmann, J ;

Zeiher, AM ;

Dimmeler, S .

FEBS LETTERS, 2004, 577 (03) :427-433

[10]

Angiotensin II-induced apoptosis in human endothelial cells is inhibited by adiponectin through restoration of the association between endothelial nitric oxide synthase and heat shock protein 90[J] . Lian-Yu Lin,Chien-Yu Lin,Ta-Chen Su,Chiau-Suong Liau.FEBS Letters . 2004 (1)

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