非酒精性脂肪性肝病与肝细胞癌

被引:13
作者
李良平
机构
[1] 四川省人民医院消化科
关键词
脂肪肝; 癌,肝细胞; 代谢综合征X;
D O I
暂无
中图分类号
R575.5 [肝代谢障碍]; R735.7 [肝肿瘤];
学科分类号
100112 [医学生物化学与分子生物学]; 100201 [内科学];
摘要
肝细胞癌(HCC)的病因正在悄然发生变化,欧美发达国家及部分亚洲国家非酒精性脂肪性肝病(NAFLD)相关HCC发病率逐渐增加。介绍了NAFLD与相关HCC的密切关系,NAFLD相关HCC的危险因素、临床病理特征及预防和筛查,指出NAFLD发病率尽管不如乙型肝炎和丙型肝炎相关HCC高,但因NAFLD基数大,其绝对数量不在少数,尤其是合并糖尿病和肥胖或肝纤维化/肝硬化高危患者。NAFLD相关HCC多见于老年,合并症较多,整体预后不佳。认为预防的重点在于有效治疗NAFLD,对高危人群进行严密筛查以便发现早期HCC,甲胎蛋白及CT等影像检查是主要的筛查方法,但目前尚缺乏针对NAFLD相关HCC早期预警的措施。
引用
收藏
页码:432 / 436
页数:5
相关论文
共 18 条
[1]
Systematic review: Preventive and therapeutic applications of metformin in liver disease[J] Aparna Bhat;Giada Sebastiani;Mamatha Bhat; World Journal of Hepatology 2015,
[2]
Characteristics of hepatocellular carcinoma in cirrhotic and non-cirrhotic non-alcoholic fatty liver disease[J] Christopher Leung;Sern Wei Yeoh;Desmond Patrick;Shara Ket;Kaye Marion;Paul Gow;Peter W Angus; World Journal of Gastroenterology 2015,
[3]
The potential role of miRNAs 21 and 199-a in early diagnosis of hepatocellular carcinoma[J] Khalda Said Amr;Wafaa M. Ezzat;Yasser A. Elhosary;Abdelfattah E. Hegazy;Hoda H. Fahim;Refaat R. Kamel Gene 2016,
[4]
The story of HCC in NAFLD : from epidemiology; across pathogenesis; to prevention and treatment[J] Cristina Margini;Jean F. Dufour Liver Int 2016,
[5]
Changing epidemiology of hepatocellular carcinoma in Asia[J] George Boon-Bee Goh;Pik-Eu Chang;Chee-Kiat Tan Best Practice & Research Clinical Gastroenterology 2015,
[6]
Obesity Early in Adulthood Increases Risk but Does Not Affect Outcomes of Hepatocellular Carcinoma[J] Manal M. Hassan;Reham Abdel-Wahab;Ahmed Kaseb;Ahmed Shalaby;Alexandria T. Phan;Hashem B. El-Serag;Ernest Hawk;Jeff Morris;Kanwal Pratap Singh Raghav;Ju-Seog Lee;Jean-Nicolas Vauthey;Gehan Bortus;Harrys A. Torres;Christopher I. Amos;Robert A. Wolff;Donghui Li Gastroenterology 2015,
[7]
Insulin and other antidiabetic drugs and hepatocellular carcinoma risk: a nested case‐control study based on Italian healthcare utilization databases[J] Cristina Bosetti;Matteo Franchi;Federica Nicotra;Rosario Asciutto;Luca Merlino;Carlo La Vecchia;Giovanni Corrao Pharmacoepidemiol Drug Saf 2015,
[8]
Clinicopathological characteristics of hepatitis B surface antigen‑negativeand hepatitis C antibody‑negative hepatocellular carcinoma[J] Hiroya Iida;Tsukasa Aihara;Shinichi Ikuta;Naoki Yamanaka Oncology Letters 2015,
[9]
Nonalcoholic Fatty Liver Disease; Diabetes; Obesity; and Hepatocellular Carcinoma[J] Mazen Noureddin;Mary E. Rinella Clinics in Liver Disease 2015,
[10]
Temporal Trends of Nonalcoholic Fatty Liver Disease–Related Hepatocellular Carcinoma in the Veteran Affairs Population[J] Sahil Mittal;Yvonne H. Sada;Hashem B. El-Serag;Fasiha Kanwal;Zhigang Duan;Sarah Temple;Sarah B. May;Jennifer R. Kramer;Peter A. Richardson;Jessica A. Davila Clinical Gastroenterology and Hepatology 2015,