NF-κB在炎症相关癌症中的双重作用

被引：9

作者：

张微峰

胡容

机构：

[1] 中国药科大学药学院

来源：

药物生物技术 | 2015年 / 22卷 / 01期

关键词：

核转录因子-κB; 炎症; 癌症; IκB家族; IκB激酶复合体; 化学预防;

D O I：

10.19526/j.cnki.1005-8915.2015.01.016

中图分类号：

R730.2 [肿瘤病理学、病因学];

学科分类号：

100214 ;

摘要：

目前,癌症是全球第二大死亡人数最多的疾病。炎症反应是一个复杂的生理学过程,涉及到生物体中细胞以及分子层面的广泛变化。在组织修复,伤口愈合以及抵御外来病原体入侵的过程中,有序的炎症反应是机体免疫系统产生的正常防御反应,保证机体的健康。但当这种急性炎症持续较长时间且得不到有效控制时,就易发展成慢性炎症,从而促进许多疾病的发生,包括风湿性关节炎,心血管疾病,阿尔茨海默症和癌症等。越来越多的证据表明,炎症反应失调在癌症中起到关键作用,长期使用非甾体类抗炎药(Non-steroidal anti-inflammatory drugs,NSAIDs)可以降低多种癌症的发病率。文章重点综述了核因子-κB(Nuclear factor-kappa B,NF-κB)在炎癌中的复杂作用,包括NF-κB对炎症反应具有的正向和负向调节作用,以及它如何影响肿瘤的发生和发展。深度解析NF-κB在炎-癌转化中的作用对于现代肿瘤生物学来说是一个重要挑战。

引用

页码：74 / 77

页数：4

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