晚期恶性肿瘤患者生存期影响因素的相关性分析

被引：17

作者：

顾筱莉 ^{[1
,2
]}

成文武 ^{[1
,2
]}

机构：

[1] 复旦大学附属肿瘤医院综合治疗科

[2] 复旦大学上海医学院肿瘤学系

来源：

中国癌症杂志 | 2013年 / 23卷 / 09期

关键词：

晚期恶性肿瘤; 危险因素; 生存期;

D O I：

暂无

中图分类号：

R730.5 [肿瘤治疗学];

学科分类号：

100214 ;

摘要：

背景与目的:晚期恶性肿瘤的预后判断在肿瘤治疗领域中非常重要,预后判断准确可以帮助临床医师选择相关的治疗。本研究旨在探讨接受姑息治疗的晚期恶性肿瘤患者的生存期相关影响因素,以期更好的指导临床。方法:回顾性分析2007年3月—2012年3月复旦大学附属肿瘤医院姑息治疗科271例死亡患者临床资料。应用Kaplan-Meier计算生存期,Log-rank检验差异性,并行Cox模型多因素分析,建立预后指数方程。结果:单因素分析显示7个相关预后因素为:卡氏评分(P<0.001)、呼吸困难(P=0.037)、瞻望(P=0.015)、外周血白细胞计数>11×109/L(P=0.012)、淋巴细胞比例<12%(P=0.030)、乳酸脱氢酶>500 U/L(P<0.001)、血清白蛋白<30 g/L(P=0.001)。其中卡式评分<30、乳酸脱氢酶>500 U/L、血清白蛋白<30 g/L、瞻望为4个独立预后因素。结论:本研究揭示了晚期恶性肿瘤患者的生存期预后相关因素,有利于临床更准确地预测患者的生存期,并提供相关治疗。

引用

页码：759 / 764

页数：6

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