瘦素与代谢综合征

被引:13
作者
周红文
机构
[1] 南京医科大学第一附属医院内分泌科!江苏南京
关键词
瘦素; 代谢综合征; 胰岛素抵抗;
D O I
暂无
中图分类号
R589 [代谢病];
学科分类号
摘要
大量临床试验表明 ,瘦素水平异常与胰岛素抵抗关系密切 ,甚至有作者认为高瘦素血症是代谢综合征的一个组成部分。对一些缺乏瘦素、具有胰岛素抵抗的动物模型的研究证实 ,瘦素能够纠正糖脂代谢紊乱、增加胰岛素敏感性 ,被认为是一个抗糖尿病的激素。瘦素能升高小鼠的血压 ,至于对人类血压的影响 ,研究结果尚存争议。
引用
收藏
页码:195 / 197
页数:3
相关论文
共 18 条
  • [1] Hyperleptinemia:The missing link in the metabolic syndrome?. de Courten M,Zimmet P,Hodge A,et al. Diabetic Medicine . 1997
  • [2] Leptin suppression of insulin secretion and gene expression in human pancreatic islets:implication for the development of adipogenic diabetes mellitus. Seufert J,Kieffer TJ,Leech CA,et al. The Journal of Clinical Endocrinology . 1999
  • [3] Diabetes[P]. 英国专利:GB201117172D0,2011-11-16
  • [4] Diabetes[P]. 英国专利:GB201117172D0,2011-11-16
  • [5] Recombinant leptin for weight loss in obese and lean adults: a randomized, controlled, dose-escalation trial. Heymsfield I S. The Journal of The American Medical Association . 1999
  • [6] Pathophysiological role of leptin in obesity-related hypertension. Aizawa-Abe M,Ogawa Y,Masuzaki H,etal. The Journal of Clinical Investigation . 2000
  • [7] Chronic leptin infusion increases arterial pressure. Shek EW,Brands MW,Hall JE. Journal of Hypertension . 1998
  • [8] Contrastingblood pressure effects of obesity in leptin deficient ob/obmice and agouti yellow obese mice. Mark A L,Shaffer R A,Correia M L G,et al. Journal of Hypertension . 1999
  • [9] Association between baseline plasma leptin levels and subsequent development of diabetes in Japanese Americans. Mcneely M J,Boyko E J,Weigle D S,et al. Diabetes Care . 1999
  • [10] Insulin and body fat distribution have no direct effect on plasma leptin levels in obese Caucasian women with and without type 2 diabetes mellitus. Bertin E,Rich N,Schneider N,et al. Diabetes and Metabolism . 1998