谷氨酸转运体、谷氨酸/胱氨酸转运体与谷氨酸神经细胞毒作用

被引:19
作者
虞希冲
机构
[1] 温州医学院药理学教研室
关键词
药理学; 综述; 谷氨酸; 谷氨酸转运体; 谷氨酸胱氨酸转运体; 神经毒性;
D O I
暂无
中图分类号
R743 [脑血管疾病];
学科分类号
摘要
谷氨酸转运体与谷氨酸 胱氨酸转运体在脑缺血疾病中起重要作用 ,谷氨酸转运体的结构或功能改变可使细胞间隙的谷氨酸浓度急剧升高 ,激活NMDA受体产生一系列的表现 ,同时抑制谷氨酸 胱氨酸转运体对胱氨酸的摄取 ,介导谷胱苷肽耗竭、氧自由基升高、胞内钙升高、线粒体损伤、细胞色素c释放等神经细胞毒环节 ,激活半胱天冬酶诱导凋亡。可进一步加重谷氨酸的神经细胞毒作用。
引用
收藏
页码:490 / 493
页数:4
相关论文
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