间充质干细胞来源外泌体在骨关节炎治疗中的作用

被引：8

作者：

黄磊 ^{[1
,2
]}

罗超 ^{[1
,2
]}

宋嘉琪 ^{[1
]}

费久旺 ^{[1
,2
]}

殷明 ^{[2
]}

机构：

[1] 南昌大学研究生院医学部

[2] 南昌大学第二附属医院骨科

来源：

生理科学进展 | 2020年 / 51卷 / 05期

关键词：

间充质干细胞; 外泌体; 骨关节炎; 软骨细胞; 治疗;

D O I：

暂无

中图分类号：

R684.3 [关节炎];

学科分类号：

100220 [骨科学];

摘要：

骨关节炎(OA)是最常见的慢性退行性骨关节疾病,目前对骨关节炎的治疗还没有特效疗法。间充质干细胞(MSC)对软骨修复有较好的疗效,间充质干细胞来源外泌体可能在这一治疗过程中发挥重要作用。外泌体是细胞间的通讯载体,能在细胞间传递生物活性脂质、核酸以及蛋白质等生物活性分子对骨关节炎产生一定影响。本文就探讨间充质干细胞来源的外泌体治疗骨关节炎过程中的作用机制与可行性做出综述。

引用

页码：362 / 366

页数：5

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