经颅磁刺激对正常大鼠脑血流量影响的即时观察

被引：12

作者：

郑修元 ^{[1
]}

何晓阔 ^{[2
]}

燕铁斌 ^{[1
]}

董军涛 ^{[1
]}

机构：

[1] 中山大学孙逸仙纪念医院康复科

[2] 湖北省十堰市太和医院康复科

来源：

中国康复医学杂志 | 2015年 / 30卷 / 05期

关键词：

重复经颅磁刺激; 激光多普勒血流仪; 脑局部血流量;

D O I：

暂无

中图分类号：

R741 [神经病学];

学科分类号：

100204 [神经病学];

摘要：

目的:动态观察不同参数设置下的重复经颅磁刺激(r TMS)对正常大鼠脑局部皮质血流量变化的影响。方法:采用经颅磁刺激仪依次连续刺激Wistar大鼠右侧大脑皮质固定区域,根据刺激参数分为4组:高频高强度(5Hz,100%)组、高频低强度(5Hz,50%)组、低频高强度(1Hz,100%)组、低频低强度(1Hz,50%)组,每组参数刺激50次;通过激光多普勒血流仪记录激光探头下大鼠脑局部皮质血流量的变化。结果:4组不同参数r TMS干预后大鼠刺激区域脑皮质局部血流量均增高,不同强度的1Hz与5Hz经颅磁刺激后脑血流量曲线变化特征不同,强度是影响脑血流量变化的重要因素,频率与强度相互不影响,脑血流随刺激结束不再变化。结论:大鼠脑血流量变化呈强度依赖性,频率影响不明显,刺激后血流量变化无后续效应。

引用

页码：417 / 421

页数：5

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