内质网应激与炎症、肥胖、脂代谢和运动关系研究进展

被引：8

作者：

温悦萌 ^{[1
,2
]}

艾华 ^{[1
,2
]}

机构：

[1] 北京大学第三医院运动医学研究所

[2] 北京大学肥胖与代谢病研究中心营养运动与肥胖研究室

来源：

中国运动医学杂志 | 2011年 / 30卷 / 09期

关键词：

内质网应激; GRP; 炎症反应; 未折叠蛋白反应;

D O I：

10.16038/j.1000-6710.2011.09.016

中图分类号：

R87 [运动医学];

学科分类号：

100216 ;

摘要：

<正>内质网是广泛分布于哺乳动物细胞内的一种重要的亚细胞器,参与蛋白质的合成、修饰加工(包括糖基化、羟基化、酰基化、二硫键形成等)、折叠、组装以及向高尔基体的运输。同时内质网也是细胞内钙离子的储存场所,在细胞内具有重要的生理功

引用

页码：870 / 873

页数：4

共 10 条

[1] The Unfolded Protein Response Mediates Adaptation to Exercise in Skeletal Muscle through a PGC-1α/ATF6α Complex [J].

Wu, Jun ;

Ruas, Jorge L. ;

Estall, Jennifer L. ;

Rasbach, Kyle A. ;

Choi, Jang Hyun ;

Ye, Li ;

Bostroem, Pontus ;

Tyra, Heather M. ;

Crawford, Robert W. ;

Campbell, Kevin P. ;

Rutkowski, D. Thomas ;

Kaufman, Randal J. ;

Spiegelman, Bruce M. .

CELL METABOLISM, 2011, 13 (02) :160-169

[2]

Assessment of Endurance Exercise Training in Hepatic Endoplasmic Reticulum Stress[J] . Natalie Ann Chapados.Methods in Enzymology . 2011

[3] Double-Stranded RNA-Dependent Protein Kinase Links Pathogen Sensing with Stress and Metabolic Homeostasis [J].

Nakamura, Takahisa ;

Furuhashi, Masato ;

Li, Ping ;

Cao, Haiming ;

Tuncman, Gurol ;

Sonenberg, Nahum ;

Gorgun, Cem Z. ;

Hotamisligil, Goekhan S. .

CELL, 2010, 140 (03) :338-U41

[4] Endoplasmic Reticulum Stress Is Reduced in Tissues of Obese Subjects After Weight Loss [J].

Gregor, Margaret F. ;

Yang, Ling ;

Fabbrini, Elisa ;

Mohammed, B. Selma ;

Eagon, J. Christopher ;

Hotamisligil, Goekhan S. ;

Klein, Samuel .

DIABETES, 2009, 58 (03) :693-700

[5] Endoplasmic Reticulum Stress Markers Are Associated with Obesity in Nondiabetic Subjects [J].

Sharma, Neeraj K. ;

Das, Swapan K. ;

Mondal, Ashis K. ;

Hackney, Oksana G. ;

Chu, Winston S. ;

Kern, Philip A. ;

Rasouli, Neda ;

Spencer, Horace J. ;

Yao-Borengasser, Aiwei ;

Elbein, Steven C. .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2008, 93 (11) :4532-4541

[6] Short-term exercise does not increase ER stress protein expression in cardiac muscle [J].

Murlasits, Zsolt ;

Lee, Youngil ;

Powers, Scott K. .

MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, 2007, 39 (09) :1522-1528

[7] Endoplasmic reticulum stress activates cleavage of CREBH to induce a systemic inflammatory response [J].

Zhang, KZ ;

Shen, XH ;

Wu, J ;

Sakaki, K ;

Saunders, T ;

Rutkowski, DT ;

Back, SH ;

Kaufman, RJ .

CELL, 2006, 124 (03) :587-599

[8] Signal transduction by the JNK group of MAP kinases [J].

Davis, RJ .

CELL, 2000, 103 (02) :239-252

[9] Stress proteins of 70 kDa in chronically exercised skeletal muscle [J].

Beatriz González ;

Raquel Hernando ;

Rafael Manso .

Pflügers Archiv, 2000, 440 (1) :42-49

[10] The transmembrane kinase Ire1p is a site-specific endonuclease that initiates mRNA splicing in the unfolded protein response [J].

Sidrauski, C ;

Walter, P .

CELL, 1997, 90 (06) :1031-1039

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