万古霉素修饰磁性纳米粒子的制备及其细菌分离功能

被引：5

作者：

柯诗剑

计剑

机构：

[1] 浙江大学高分子科学与工程系高分子合成与功能构造教育部重点实验室

来源：

高等学校化学学报 | 2007年 / 01期

关键词：

磁性纳米粒子; 万古霉素; 生物缔合; 细菌分离;

D O I：

暂无

中图分类号：

TQ465 [抗菌素制造];

学科分类号：

100705 ;

摘要：

APTES-bounded MNP were prepared by chemical coprecipitation,followed by coating with((γ-aminopropyl))triethoxysilane.Norvancomycin hydrochloride(Van) was then immobilized onto the amino-functionalized nanopartiles.Powder X-ray diffraction(XRD) results show the inverse spinel structure of MNP.The physics property measurement system(PPMS) indicates that the MNP are superparamagnetic.The presence of Van and APTES on the surface of MNP is confirmed by FTIR.By a separation assay of S.aureus and E.coli BL21,it is proved that MNP-APTES-Van can selectively capture S.aureus within 10 min,which can be isolated readily by applying an external magnetic field.

引用

页码：26 / 28

页数：3