冠脉支架术后长期联合应用阿司匹林和氯吡格雷的疗效及安全性研究

被引：8

作者：

王东明

岳传哲

陈宋明

房小袆

丁洽烽

机构：

[1] 汕头大学医学院第一附属医院心内科

[2] 汕头大学医学院第一附属医院心内科广东省汕头市

[3] 广东省汕头市

来源：

中国全科医学 | 2005年 / 21期

关键词：

氯吡格雷; 抗血小板治疗; 冠脉支架术; 急性冠脉综合征;

D O I：

暂无

中图分类号：

R543.3 [冠状动、静脉疾病];

学科分类号：

1002 ; 100201 ;

摘要：

目的观察冠脉支架术后联合应用阿司匹林和氯吡格雷的疗效及安全性。方法将行冠脉支架术的136例非ST段抬高的急性冠脉综合征患者随机分为试验组(70例)和对照组(66例)。试验组在冠脉支架术后长期联合应用(6～12个月,平均9个月)阿司匹林和氯吡格雷至随访结束;对照组在PCI术后联合应用阿司匹林和氯吡格雷1个月,以后长期应用阿司匹林。观察两组患者主要心血管事件(心血管性死亡、心肌梗死、心肌缺血复发进行靶血管再通治疗)及出血(严重出血、轻微出血)的发生率。结果试验组发生7例心血管事件(心肌梗死2例、靶血管再通治疗5例);对照组发生16例心血管事件(心血管性死亡1例,心肌梗死4例,靶血管再通治疗11例),两组间差异有显著性意义(P<0.05);两组均无严重出血,轻微出血率间差异无显著性意义(P>0.05)。结论冠脉支架术后长期联合应用阿司匹林和氯吡格雷安全、有效,可减少冠脉支架术后心血管事件的发生,出血并发症无明显增加。

引用

页码：27 / 28

页数：2

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