五味子藤茎中木脂素和多糖成分对小鼠急性酒精肝损伤的保护作用

被引：12

作者：

刘群

李伟

郑毅男

机构：

[1] 吉林农业大学中药材学院

来源：

辽宁中医药大学学报 | 2013年 / 15卷 / 11期

关键词：

五味子藤茎; 木脂素; 多糖; 酒精; 肝损伤;

D O I：

10.13194/j.issn.1673-842x.2013.11.066

中图分类号：

R285.5 [中药实验药理];

学科分类号：

100806 [中药药理学];

摘要：

目的:研究五味子藤茎木脂素和多糖对急性酒精肝损伤的保护作用。方法:除空白对照组外,其余各组小鼠酒精灌胃给药造成急性肝损伤。应用酶标法测定小鼠血清中谷氨酸转氨酶(ALT)、天门冬氨酸转氨酶(AST)活性和甘油三酯(TG)浓度,并测定小鼠肝脏中超氧化物歧化酶(SOD)活性及丙二醛(MDA)浓度。结果:与模型组相比,五味子木脂素和多糖高、中、低剂量能不同程度地降低血清中ALT、AST活性及TG浓度,升高肝脏中SOD的活性并抑制MDA浓度的上升。其中,高剂量的作用效果与联苯双酯作用相当,但二者对各指标的作用程度不同。结论:五味子藤茎木脂素和多糖对酒精诱导的急性肝损伤有一定的保护作用,二者的作用机制可能与抗氧化作用有关。

引用

页码：32 / 34

页数：3

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