普拉克索对老年帕金森病伴抑郁的疗效及机制研究

被引:8
作者
白抚生 [1 ,2 ]
尤林 [1 ,2 ]
谢欣 [1 ,2 ]
雷鸿雁 [1 ,2 ]
刘斌 [1 ,2 ]
机构
[1] 辽宁省金秋医院
[2] 辽宁省老年病研究院神经内科
关键词
帕金森病; 抑郁; 普拉克索; BDI Ⅱ抑郁量表;
D O I
暂无
中图分类号
R742.5 [震颤麻痹综合征];
学科分类号
100204 [神经病学];
摘要
<正>近年来,随着帕金森病(PD)的诊断及其运动症状治疗水平的提高,其非运动症状也得到越来越多的关注。所谓非运动症状是针对运动症状(静止性震颤、肌强直、运动减少、体位姿势障碍)而言,主要包括感觉障碍、睡眠障碍、精神障碍、认知功能障碍,自主神经功能障碍等。抑郁是PD精神障碍的最常见症状,其发生率为40%50%[1]。本研究比较多巴胺受体激动剂普拉克索和对比抗抑郁药物选择性5-羟色胺再摄取抑制剂(SSRIs)盐酸舍曲林对老年PD伴抑郁
引用
收藏
页码:201 / 202
页数:2
相关论文
共 7 条
[1]
Pramipexole for depression and motor symptoms in Parkinson's disease: can we kill two birds with one stone? [J].
Fernandez, Hubert H. ;
Merello, Marcelo .
LANCET NEUROLOGY, 2010, 9 (06) :556-557
[2]
Effects of the dopamine agonist pramipexole on depression; anhedonia and motor functioning in Parkinson's disease.[J].Matthias R. Lemke;H. Michael Brecht;Juergen Koester;Heinz Reichmann.Journal of the Neurological Sciences.2006, 1
[3]
Pramipexole versus sertraline in the treatment of depression in Parkinson’s disease:A national multicenter parallel–group randomized study.[J].P. Barone;L. Scarzella;R. Marconi;A. Antonini;L. Morgante;F. Bracco;M. Zappia;B. Musch.Journal of Neurology.2006, 5
[4]
Depression in Parkinson's disease – a review.[J].A.Lieberman.Acta Neurologica Scandinavica.2005, 1
[5]
The use of pramipexole in Parkinson's disease:: are its actions D3 mediated? [J].
Guttman, M ;
Jaskolka, J .
PARKINSONISM & RELATED DISORDERS, 2001, 7 (03) :231-234
[6]
The D3 dopamine receptor in cellular and organismal function [J].
Shafer, RA ;
Levant, B .
PSYCHOPHARMACOLOGY, 1998, 135 (01) :1-16
[7]
Depression in Parkinsonʼs Disease.[J].SERGIO E. STARKSTEIN;THOMAS J. PREZIOSI;PAULA L. BOLDUC;ROBERT G. ROBINSON.The Journal of Nervous and Mental Disease.1990, 1