转基因耐草甘膦除草剂玉米CC-2喂养SD大鼠90天亚慢性毒性研究

被引：6

作者：

陈德龙 ^{[1
]}

张莳眉 ^{[1
]}

邹世颖 ^{[1
]}

刘一非 ^{[1
]}

周忻 ^{[1
,2
]}

贺晓云 ^{[1
,2
]}

黄昆仑 ^{[1
,2
]}

机构：

[1] 中国农业大学食品科学与营养工程学院

[2] 农业部转基因生物食用安全监督检验测试中心

来源：

农业生物技术学报 | 2013年 / 21卷 / 12期

关键词：

耐除草剂; 转基因玉米; 草甘膦; SD大鼠; 90 d喂养实验;

D O I：

暂无

中图分类号：

S513 [玉米（玉蜀黍）]; S865.12 [];

学科分类号：

摘要：

为了评估转基因耐除草剂玉米中长期喂养Sprague-Dawley(SD)大鼠的安全性,本研究将转基因耐草甘膦除草剂玉米(CC-2)及其非转基因对照玉米(郑-58)分别以12.5%、25%和50%的比例添加到基础饲料中,饲喂SD大鼠90 d,检测其对SD大鼠营养状况和生理指标的影响,实验期间,观察各组动物的体重、血常规以及血生化指标,实验末期解剖动物进行大体病理观察,计算脏器系数。结果显示,转基因玉米喂养动物90 d后,各组动物生长发育良好,转基因玉米组与非转基因玉米对照组相比,SD大鼠的血生化、血常规、脏器系数等个别指标有统计学差异(P<0.05),但这些差异无剂量相关性,无生物学意义。研究表明,长期饲喂转基因耐除草剂玉米CC-2与非转基因玉米对SD大鼠具有同样的安全性。本研究为转基因玉米的安全应用提供了科学数据支持。

引用

页码：1448 / 1457

页数：10

共 13 条

[1]

Safety testing of GM-rice expressing PHA-E lectin using a new animal test design[J] . &nbspFood and Chemical Toxicology . 2006 (3)

[2]

Thirteen week feeding study with transgenic maize grain containing event DAS-?15?7-1 in Sprague–Dawley rats[J] . Susan A. MacKenzie,Ian Lamb,Jean Schmidt,Lora Deege,Michael J. Morrisey,Marc Harper,Raymond J. Layton,Lee M. Prochaska,Craig Sanders,Mary Locke,Joel L. Mattsson,Angel Fuentes,Bryan Delaney. &nbspFood and Chemical Toxicology . 2006 (4)

[3]

Biotechnology and food safety. FAO/WHO. Report of Second Joint FAO/WHO Consultation . 1996

[4]

Safety and nutritional assessment of GM plants and derived food and feed: The role of animal feeding trials. Report of the EFSA GMO Panel Working Group on Animal Feeding Trials. Food and Chemical Toxicology . 2008

[5]

Consensus Document on Compositional Considerations for New Varieties of Maize (Zea mays):Key Food and Feed Nutrients,Antinutrients,and Secondary Plant Metabolites. OECD. Series on the Safety of Novel Foods and Feeds No.6 . 2002

[6]

Development of real-time PCR systems based on SYBR ? Green I, Amplifluor? and TaqMan ? technologies for specific quantitative detection of the transgenic maize event GA21[J] . Marta Hernández,Teresa Esteve,Salomé Prat,Maria Pla. &nbspJournal of Cereal Science . 2003 (1)

[7] Comparative safety testing of genetically modified foods in a 90-day rat feeding study design allowing the distinction between primary and secondary effects of the new genetic event [J].