核转录因子-κB在骨关节炎炎症反应中的作用

被引：9

作者：

应俊 ^{[1
]}

张元斌 ^{[1
]}

罗程 ^{[1
]}

金红婷 ^{[1
]}

肖鲁伟 ^{[1
]}

童培建 ^{[2
]}

机构：

[1] 浙江中医药大学

[2] 浙江省中医院

来源：

中医正骨 | 2015年 / 07期

关键词：

NF-κB; 骨关节炎; 综述;

D O I：

暂无

中图分类号：

R684.3 [关节炎];

学科分类号：

100220 [骨科学];

摘要：

核转录因子κB(nuclear factor-kappa B,NF-κB)是机体中极为重要的转录因子,参与机体的炎症与免疫反应、凋亡与抗凋亡以及细胞的周期调控与发育等诸多功能的调节。NF-κB信号通路在关节软骨的发育及骨关节炎的发生、发展中扮演着重要角色。本文对NF-κB及其信号通路进行了简单的介绍,并从NF-κB信号通路、NF-κB核移位在骨关节炎炎症反应中的作用以及基于NF-k B治疗骨关节炎的药物研究3个方面对NF-κB在骨关节炎炎症反应中的作用进行了综述。

引用

页码：40 / 43+47 +47

页数：5

共 16 条

[1]

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陈连旭 ;

于长隆 .

中国组织工程研究, 2012, 16 (46) :8551-8555

[2]

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