以表皮生长因子受体为靶向的肿瘤信号转导干预治疗

Olayioye MA,Neve RM,Lane HA,et al.The ErbB signaling network: receptor heterodimerization in development and cancer. EMBO Journal . 2000

Joazeiro CA,Wing SS,Huang H,et al.The tyrosine kinase negative regulator c-Cb1 as a RING-type, E2-dependent ubiquitin-protein ligase. Science . 1999

Biswas DK,Cruz AP,Gansberger E,et al.Epidermal growth factor-induced nuclear factorκB activation: A major pathway of cell-cycle progression in estrogen-receptor negative breast cancer cells. Proceedings of the National Academy of Sciences of the United States of America . 2000

Shi W,Fan H,Shum L,et al.The tetraspanin CD9 associated with transmembrane TGF-alpha and regulates TGF-alpha induced EGF receptor activiation and cell proliferation. The Journal of Cell Biology . 2000

Reardon DB,Contessa JN,Mikkelsen RB,et al.Dominant negative EGFR-CD533 and inhibition of MAPK modify JNK1 activation and enhance radiation toxicity of human mammary cacinoma cells. Oncegene . 1999

Huang SM,Harari PM.Modulation of radiation response after epidermal growth factor receptor blockade in squamous cell carcinomas: inhibition of damage repair, cell cycle kinetics, and tumor angiogenesis. J Clin Cancer Res . 2000

Beers R,Chowdhury P,Bigner D,et al.Immnotoxins with increased activity against epidermal growth factor receptor vⅢ-expressing cells produced by antibody phage display. Clinical Cancer Research . 2000

Gutacker C,Klock G,Diel P,et al.Nerve growth factor and epidermal growth factor stimulate clusterin gene expression in PC12 cells. Biochemical Journal . 1999

Azemar M,Schmidt M,Arlt F,et al.Recombinant antibody toxins specific for ErbB2 and EGF receptor inhibit the in vitro growth of human head and neck cancer cells and causer rapid tumor regression in vivo. International Journal of Cancer . 2000

Wong L,Deb TB,Thompson SA,et al.A differential requirement for the COOH-terminal region of the epidermal growth factor(EGF)receptor in amphiregulin and EGF mitogenic signaling. Journal of Biological Chemistry . 1999

Olayioye MA,Neve RM,Lane HA,et al.The ErbB signaling network: receptor heterodimerization in development and cancer. EMBO Journal . 2000

Joazeiro CA,Wing SS,Huang H,et al.The tyrosine kinase negative regulator c-Cb1 as a RING-type, E2-dependent ubiquitin-protein ligase. Science . 1999

Biswas DK,Cruz AP,Gansberger E,et al.Epidermal growth factor-induced nuclear factorκB activation: A major pathway of cell-cycle progression in estrogen-receptor negative breast cancer cells. Proceedings of the National Academy of Sciences of the United States of America . 2000

Shi W,Fan H,Shum L,et al.The tetraspanin CD9 associated with transmembrane TGF-alpha and regulates TGF-alpha induced EGF receptor activiation and cell proliferation. The Journal of Cell Biology . 2000

Reardon DB,Contessa JN,Mikkelsen RB,et al.Dominant negative EGFR-CD533 and inhibition of MAPK modify JNK1 activation and enhance radiation toxicity of human mammary cacinoma cells. Oncegene . 1999

Huang SM,Harari PM.Modulation of radiation response after epidermal growth factor receptor blockade in squamous cell carcinomas: inhibition of damage repair, cell cycle kinetics, and tumor angiogenesis. J Clin Cancer Res . 2000

Beers R,Chowdhury P,Bigner D,et al.Immnotoxins with increased activity against epidermal growth factor receptor vⅢ-expressing cells produced by antibody phage display. Clinical Cancer Research . 2000

Gutacker C,Klock G,Diel P,et al.Nerve growth factor and epidermal growth factor stimulate clusterin gene expression in PC12 cells. Biochemical Journal . 1999

Azemar M,Schmidt M,Arlt F,et al.Recombinant antibody toxins specific for ErbB2 and EGF receptor inhibit the in vitro growth of human head and neck cancer cells and causer rapid tumor regression in vivo. International Journal of Cancer . 2000

Wong L,Deb TB,Thompson SA,et al.A differential requirement for the COOH-terminal region of the epidermal growth factor(EGF)receptor in amphiregulin and EGF mitogenic signaling. Journal of Biological Chemistry . 1999